Honghua Extract Mediated Potent Inhibition of COVID-19 Host Cell Pathways

Overview

Journal Sci Rep

Specialty Science

Date 2022 Aug 22

PMID 35995784

Authors

Malika Madikyzy

Meruyert Tilegen

Guldan Nazarbek

Chenglin Mu

Aidana Kutzhanova

Xugang Li

Cuiping Ma

Yingqiu Xie

Affiliations

Soon will be listed here.

Abstract

Honghua (Carthami flos) and Xihonghua (Croci stigma) have been used in anti-COVID-19 as Traditional Chinese Medicine, but the mechanism is unclear. In this study, we applied network pharmacology by analysis of active compounds and compound-targets networks, enzyme kinetics assay, signaling pathway analysis and investigated the potential mechanisms of anti-COVID-19. We found that both herbs act on signaling including kinases, response to inflammation and virus. Moreover, crocin likely has an antiviral effect due to its high affinity towards the human ACE2 receptor by simulation. The extract of Honghua and Xihonghua exhibited nanozyme/herbzyme activity of alkaline phosphatase, with distinct fluorescence. Thus, our data suggest the great potential of Honghua in the development of anti-COVID-19 agents.

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