Decorin As a Possible Strategy for the Amelioration of COVID-19

Overview

Journal Med Hypotheses

Specialty General Medicine

Date 2021 Jun 7

PMID 34098463

Citations 9

Authors

Prince Allawadhi

Vishakha Singh

Isha Khurana

Pushkar Singh Rawat

Akshata Patangrao Renushe

Amit Khurana

Umashanker Navik

Sachin Allwadhi

Satish Kumar Karlapudi

Anil Kumar Banothu

Kala Kumar Bharani

Affiliations

Soon will be listed here.

Abstract

Coronavirus pandemic has emerged as an extraordinary healthcare crisis in modern times. The SARS-CoV-2 novel coronavirus has high transmission rate, is more aggressive and virulent in comparison to previously known coronaviruses. It primarily attacks the respiratory system by inducing cytokine storm that causes systemic inflammation and pulmonary fibrosis. Decorin is a pluripotent molecule belonging to a leucine rich proteoglycan group that exerts critical role in extracellular matrix (ECM) assembly and regulates cell growth, adhesion, proliferation, inflammation, and fibrogenesis. Interestingly, decorin has potent anti-inflammatory, cytokine inhibitory, and anti-fibrillogenesis effects which make it a potential drug candidate against the COVID-19 related complications especially in the context of lung fibrosis. Herein, we postulate that owing to its distinctive pharmacological actions and immunomodulatory effect, decorin can be a promising preclinical therapeutic agent for the therapy of COVID-19.

Citing Articles

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