Skin Tissue Perfusion Mapping Triggered by an Audio-(de)modulated Reference Signal

Overview

Journal Biomed Opt Express

Specialty Radiology

Date 2022 Aug 22

PMID 35991927

Authors

Stefan Borik

Patrik Procka

Jakub Kubicek

Christoph Hoog Antink

Affiliations

Soon will be listed here.

Abstract

Spatial mapping of skin perfusion provides essential information about physiological processes that are often hidden from the eyes of the examining physician. The perfusion map quality depends on several key factors, such as the camera system type, frame rate, sensitivity, or signal-to-noise ratio. When investigating physiological parameters, the reference signal allows for increasing the spatial resolution of the photoplethysmography imaging (PPGI) system. On the other hand, it increases the system complexity and the synchronization prerequisites. Our solution is a hardware device that modulates the reference biosignal into the audio frequency band. This signal is connected to the mic input of a digital camera or a smartphone, enabling the transformation of such a device into a PPGI measurement system even in the case of compressed video recording using lock-in amplification technique. It also brings the possibility of synchronous recording of PPGI and another reference signal such as conventional photoplethysmogram or electrocardiogram.

Citing Articles

Low-cost camera-based assessment of venous hemodynamics in the lower limbs: a study on young healthy volunteers.

Badiola I, Seleng J, Silva D, Blazek V, Leonhardt S, Lueken M Biomed Opt Express. 2025; 16(2):520-534.

PMID: 39958860 PMC: 11828450. DOI: 10.1364/BOE.547794.

Non-contact measurement of neck pulses achieved by imaging micro-motions in the neck skin.

He Q, Geng W, Li W, Wang R Biomed Opt Express. 2023; 14(9):4507-4519.

PMID: 37791270 PMC: 10545184. DOI: 10.1364/BOE.501749.

References

Verkruysse W, Svaasand L, Nelson J . Remote plethysmographic imaging using ambient light. Opt Express. 2008; 16(26):21434-45. PMC: 2717852. DOI: 10.1364/oe.16.021434. View

Blanik N, Abbas A, Venema B, Blazek V, Leonhardt S . Hybrid optical imaging technology for long-term remote monitoring of skin perfusion and temperature behavior. J Biomed Opt. 2014; 19(1):16012. DOI: 10.1117/1.JBO.19.1.016012. View

Sun Y, Hu S, Azorin-Peris V, Kalawsky R, Greenwald S . Noncontact imaging photoplethysmography to effectively access pulse rate variability. J Biomed Opt. 2012; 18(6):061205. DOI: 10.1117/1.JBO.18.6.061205. View

de Haan G, van Leest A . Improved motion robustness of remote-PPG by using the blood volume pulse signature. Physiol Meas. 2014; 35(9):1913-1926. DOI: 10.1088/0967-3334/35/9/1913. View

Wang W, den Brinker A, Stuijk S, de Haan G . Algorithmic Principles of Remote PPG. IEEE Trans Biomed Eng. 2017; 64(7):1479-1491. DOI: 10.1109/TBME.2016.2609282. View

Guler N, Fidan U . Wireless transmission of ECG signal. J Med Syst. 2006; 30(3):231-5. DOI: 10.1007/s10916-005-7980-5. View

Poh M, McDuff D, Picard R . Advancements in noncontact, multiparameter physiological measurements using a webcam. IEEE Trans Biomed Eng. 2010; 58(1):7-11. DOI: 10.1109/TBME.2010.2086456. View

Jurak P, Halamek J, Meluzin J, Plesinger F, Postranecka T, Lipoldova J . Ventricular dyssynchrony assessment using ultra-high frequency ECG technique. J Interv Card Electrophysiol. 2017; 49(3):245-254. PMC: 5543201. DOI: 10.1007/s10840-017-0268-0. View

Elgendi M, Fletcher R, Liang Y, Howard N, Lovell N, Abbott D . The use of photoplethysmography for assessing hypertension. NPJ Digit Med. 2019; 2:60. PMC: 6594942. DOI: 10.1038/s41746-019-0136-7. View

10.

Perlitz V, Cotuk B, Lambertz M, Grebe R, Schiepek G, Petzold E . Coordination dynamics of circulatory and respiratory rhythms during psychomotor drive reduction. Auton Neurosci. 2004; 115(1-2):82-93. DOI: 10.1016/j.autneu.2004.07.007. View

11.

Kamshilin A, Miridonov S, Teplov V, Saarenheimo R, Nippolainen E . Photoplethysmographic imaging of high spatial resolution. Biomed Opt Express. 2011; 2(4):996-1006. PMC: 3072138. DOI: 10.1364/BOE.2.000996. View

12.

Maheshkumar K, Dilara K, Maruthy K, Sundareswaren L . Validation of PC-based Sound Card with Biopac for Digitalization of ECG Recording in Short-term HRV Analysis. N Am J Med Sci. 2016; 8(7):307-11. PMC: 4982360. DOI: 10.4103/1947-2714.187150. View

13.

McDuff D, Nishidate I, Nakano K, Haneishi H, Aoki Y, Tanabe C . Non-contact imaging of peripheral hemodynamics during cognitive and psychological stressors. Sci Rep. 2020; 10(1):10884. PMC: 7331808. DOI: 10.1038/s41598-020-67647-6. View

14.

de Haan G, Jeanne V . Robust pulse rate from chrominance-based rPPG. IEEE Trans Biomed Eng. 2013; 60(10):2878-86. DOI: 10.1109/TBME.2013.2266196. View

15.

Pan J, Tompkins W . A real-time QRS detection algorithm. IEEE Trans Biomed Eng. 1985; 32(3):230-6. DOI: 10.1109/TBME.1985.325532. View

16.

Wang W, Stuijk S, de Haan G . A Novel Algorithm for Remote Photoplethysmography: Spatial Subspace Rotation. IEEE Trans Biomed Eng. 2015; 63(9):1974-1984. DOI: 10.1109/TBME.2015.2508602. View

17.

Kligfield P, Gettes L, Bailey J, Childers R, Deal B, Hancock E . Recommendations for the standardization and interpretation of the electrocardiogram: part I: The electrocardiogram and its technology: a scientific statement from the American Heart Association Electrocardiography and Arrhythmias Committee, Council.... Circulation. 2007; 115(10):1306-24. DOI: 10.1161/CIRCULATIONAHA.106.180200. View