Ventricular Dyssynchrony Assessment Using Ultra-high Frequency ECG Technique

Overview

Journal J Interv Card Electrophysiol

Publisher Springer

Date 2017 Jul 12

PMID 28695377

Citations 9

Authors

Pavel Jurak

Josef Halamek

Jaroslav Meluzin

Filip Plesinger

Tereza Postranecka

Jolana Lipoldova

Miroslav Novak

Vlastimil Vondra

Ivo Viscor

Ladislav Soukup

Petr Klimes

Petr Vesely

Josef Sumbera

Karel Zeman

Roshini S Asirvatham

Jason Tri

Samuel J Asirvatham

Pavel Leinveber

Affiliations

Soon will be listed here.

Abstract

Purpose: The aim of this proof-of-concept study is to introduce new high-dynamic ECG technique with potential to detect temporal-spatial distribution of ventricular electrical depolarization and to assess the level of ventricular dyssynchrony.

Methods: 5-kHz 12-lead ECG data was collected. The amplitude envelopes of the QRS were computed in an ultra-high frequency band of 500-1000 Hz and were averaged (UHFQRS). UHFQRS V lead maps were compiled, and numerical descriptor identifying ventricular dyssynchrony (UHFDYS) was detected.

Results: An electrical UHFQRS maps describe the ventricular dyssynchrony distribution in resolution of milliseconds and correlate with strain rate results obtained by speckle tracking echocardiography. The effect of biventricular stimulation is demonstrated by the UHFQRS morphology and by the UHFDYS descriptor in selected examples.

Conclusions: UHFQRS offers a new and simple technique for assessing electrical activation patterns in ventricular dyssynchrony with a temporal-spatial resolution that cannot be obtained by processing standard surface ECG. The main clinical potential of UHFQRS lies in the identification of differences in electrical activation among CRT candidates and detection of improvements in electrical synchrony in patients with biventricular pacing.

Citing Articles

Quest for the ideal assessment of electrical ventricular dyssynchrony in cardiac resynchronization therapy.

Nguyen U, Vernooy K, Prinzen F J Mol Cell Cardiol Plus. 2025; 7():100061.

PMID: 39802441 PMC: 11708375. DOI: 10.1016/j.jmccpl.2024.100061.

Ultra-High-Frequency ECG in Cardiac Pacing and Cardiac Resynchronization Therapy: From Technical Concept to Clinical Application.

Nguyen U, Rijks J, Plesinger F, Rademakers L, Luermans J, Smits K J Cardiovasc Dev Dis. 2024; 11(3).

PMID: 38535099 PMC: 10970776. DOI: 10.3390/jcdd11030076.

Ultra-high-frequency ECG volumetric and negative derivative epicardial ventricular electrical activation pattern.

Leinveber P, Halamek J, Curila K, Prinzen F, Lipoldova J, Matejkova M Sci Rep. 2024; 14(1):5681.

PMID: 38454102 PMC: 10920693. DOI: 10.1038/s41598-024-55789-w.

Cardiac resynchronization considerations in left bundle branch block.

Kong N, Upadhyay G Front Physiol. 2022; 13:962042.

PMID: 36187776 PMC: 9520457. DOI: 10.3389/fphys.2022.962042.

Skin tissue perfusion mapping triggered by an audio-(de)modulated reference signal.

Borik S, Procka P, Kubicek J, Hoog Antink C Biomed Opt Express. 2022; 13(7):4058-4070.

PMID: 35991927 PMC: 9352299. DOI: 10.1364/BOE.461087.

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