» Articles » PMID: 35989522

Serum Non-coding RNAs for Diagnosis and Stage of Liver Fibrosis

Overview
Journal J Clin Lab Anal
Publisher Wiley
Date 2022 Aug 22
PMID 35989522
Authors
Affiliations
Soon will be listed here.
Abstract

Background: All chronic liver diseases could lead to liver fibrosis. Accurate diagnosis and stage of fibrosis were important for the medical determination, management, and therapy. Liver biopsy was considered to be the gold criteria of fibrosis diagnosis. However, liver biopsy was an invasive method with some drawbacks. Non-invasive tests for liver fibrosis included radiologic method and serum-based test. Radiologic examination was influenced by obesity, cost, and availability. Serum-based test was widely used in the screening and diagnostic of liver fibrosis. However, the accuracy was still needed to be improved.

Methods: Recent studies showed serum non-coding RNAs: microRNA, long non-coding RNA(lncRNA), and circular RNA(circRNA), which have the potentiality to be non-invasive markers for liver fibrosis. The recent progress was summarized in this review.

Results: These studies showed serum non-coding RNAs exerted a good diagnostic performance for liver fibrosis. A panel that included several non-coding RNAs could increase the accuracy of single marker.

Conclusions: Serum microRNAs, lncRNAs, and circRNAs could be potential non-invasive markers for diagnosis and stage of liver fibrosis. More high-quality clinical study is needed for further research.

Citing Articles

Identification of serum tsRNA-Thr-5-0015 and combined with AFP and PIVKA-II as novel biomarkers for hepatocellular carcinoma.

Jin K, Wu J, Yang J, Chen B, Xu J, Bao H Sci Rep. 2024; 14(1):28834.

PMID: 39572775 PMC: 11582641. DOI: 10.1038/s41598-024-80592-y.


New Biomarkers in Liver Fibrosis: A Pass through the Quicksand?.

Tagliaferro M, Marino M, Basile V, Pocino K, Rapaccini G, Ciasca G J Pers Med. 2024; 14(8).

PMID: 39201990 PMC: 11355846. DOI: 10.3390/jpm14080798.


Liquid Liver Biopsy for Disease Diagnosis and Prognosis.

Tsoneva D, Ivanov M, Vinciguerra M J Clin Transl Hepatol. 2024; 11(7):1520-1541.

PMID: 38161500 PMC: 10752811. DOI: 10.14218/JCTH.2023.00040.


Serum non-coding RNAs for diagnosis and stage of liver fibrosis.

Liu C, Hou X, Mo K, Li N, An C, Liu G J Clin Lab Anal. 2022; 36(10):e24658.

PMID: 35989522 PMC: 9550980. DOI: 10.1002/jcla.24658.

References
1.
Ludwig N, Leidinger P, Becker K, Backes C, Fehlmann T, Pallasch C . Distribution of miRNA expression across human tissues. Nucleic Acids Res. 2016; 44(8):3865-77. PMC: 4856985. DOI: 10.1093/nar/gkw116. View

2.
Anwar S, Krech T, Hasemeier B, Schipper E, Schweitzer N, Vogel A . Loss of imprinting and allelic switching at the DLK1-MEG3 locus in human hepatocellular carcinoma. PLoS One. 2012; 7(11):e49462. PMC: 3493531. DOI: 10.1371/journal.pone.0049462. View

3.
Pan Y, Wang J, He L, Zhang F . MicroRNA-34a Promotes EMT and Liver Fibrosis in Primary Biliary Cholangitis by Regulating TGF-1/smad Pathway. J Immunol Res. 2021; 2021:6890423. PMC: 8087466. DOI: 10.1155/2021/6890423. View

4.
Deng Z, He Y, Yang X, Shi H, Shi A, Lu L . MicroRNA-29: A Crucial Player in Fibrotic Disease. Mol Diagn Ther. 2017; 21(3):285-294. DOI: 10.1007/s40291-016-0253-9. View

5.
Wang S, Jiang J, Zhang C, Zhang X, Wang C . Serum lincRNA-p21 expression in primary liver diseases and liver metastatic diseases. Pathol Res Pract. 2019; 215(4):779-783. DOI: 10.1016/j.prp.2019.01.014. View