Current Therapy Option for Necrotizing Enterocolitis: Practicalities and Challenge

Overview

Journal Front Pediatr

Specialty Pediatrics

Date 2022 Aug 15

PMID 35967586

Authors

Huihuan Wu

Kehang Guo

Zewei Zhuo

Ruijie Zeng

Yujun Luo

Qi Yang

Jingwei Li

Rui Jiang

Zena Huang

Weihong Sha

Hao Chen

Affiliations

Soon will be listed here.

Abstract

Necrotizing enterocolitis (NEC) is one of the most prevalent neonatal gastrointestinal disorders. Despite ongoing breakthroughs in its treatment and prevention, the incidence and mortality associated with NEC remain high. New therapeutic approaches, such as breast milk composition administration, stem cell therapy, immunotherapy, and fecal microbiota transplantation (FMT) have recently evolved the prevention and the treatment of NEC. This study investigated the most recent advances in NEC therapeutic approaches and discussed their applicability to bring new insight to NEC treatment.

Citing Articles

Gut Microbiota-Derived Metabolites and Their Role in the Pathogenesis of Necrotizing Enterocolitis in Preterm Infants: A Narrative Review.

Provitera L, Tomaselli A, Algieri F, Tripodi M, Raffaeli G, Amodeo I Metabolites. 2024; 14(11).

PMID: 39590806 PMC: 11596930. DOI: 10.3390/metabo14110570.

Plant-Derived Substances for Prevention of Necrotising Enterocolitis: A Systematic Review of Animal Studies.

Mackay C, Rath C, Rao S, Patole S Nutrients. 2024; 16(6).

PMID: 38542743 PMC: 10975714. DOI: 10.3390/nu16060832.

[Effect of gut microbiota homeostasis on hematopoiesis in a neonatal rat model of necrotizing enterocolitis].

Wang S, Cai J, Shi A, Cao Y Zhongguo Dang Dai Er Ke Za Zhi. 2023; 25(8):855-863.

PMID: 37668035 PMC: 10484087. DOI: 10.7499/j.issn.1008-8830.2301082.

Progress in Research on Stem Cells in Neonatal Refractory Diseases.

Huang F, He Y, Zhang M, Luo K, Li J, Li J J Pers Med. 2023; 13(8).

PMID: 37623531 PMC: 10455340. DOI: 10.3390/jpm13081281.

Human Bone Marrow-Derived Mesenchymal Stromal Cells Reduce the Severity of Experimental Necrotizing Enterocolitis in a Concentration-Dependent Manner.

Provitera L, Tomaselli A, Raffaeli G, Crippa S, Arribas C, Amodeo I Cells. 2023; 12(5).

PMID: 36899900 PMC: 10000931. DOI: 10.3390/cells12050760.

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