Hydrogen Sulfide and Substance P Levels in Patients with and Bacteraemia

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2022 Aug 12

PMID 35955767

Authors

Sumeet Manandhar

Amy Scott-Thomas

Michael Harrington

Priyanka Sinha

Anna Pilbrow

Arthur Mark Richards

Vicky Cameron

Madhav Bhatia

Stephen T Chambers

Affiliations

Soon will be listed here.

Abstract

Hydrogen sulfide (HS) and substance P (SP) are known from animal models and in vitro studies as proinflammatory mediators. In this study, peripheral blood concentrations of HS and SP were measured in patients with or bacteraemia. Fifty patients were recruited from general wards at Christchurch Hospital, during 2020-2021. Samples from age- and sex-matched healthy subjects previously recruited as controls for studies of cardiovascular disease were used as controls. The concentrations of HS were higher than controls on day 0, day 1, and day 2, and SP was higher than controls on all 4 days. The concentrations of HS were highest on day 0, whereas SP concentrations were higher on day 2 than other days. Interleukin-6 and C-reactive protein were significantly higher on day 0 and day 1, respectively. The concentrations of HS and SP did not differ between 15 non-septic (SIRS 0-1) and the 35 septic subjects (SIRS ≥ 2). Substance P concentrations were higher in subjects with abdominal infection than urinary tract infections on day 0 ( = 0.0002) and day 1 ( = 0.0091). In conclusion, the peak HS concentrations precede the SP peak in patients with Gram-negative bacteraemia, but this response varies with the site of infection.

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