Sustained Low Serum Substance P Levels in Non-Surviving Septic Patients

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2017 Jul 18

PMID 28714876

Citations 5

Authors

Leonardo Lorente

Maria M Martin

Antonia Perez-Cejas

Jose Ferreres

Jordi Sole-Violan

Lorenzo Labarta

Cesar Diaz

Alejandro Jimenez

Affiliations

Soon will be listed here.

Abstract

Previously, researchers found higher serum substance P (SP) concentrations in survivors of severe sepsis than in non-survivors at the time of severe sepsis diagnosis. The objectives of our current study were to determine whether there is an association between serum SP levels during the first week and sepsis mortality, sepsis severity, serum levels of tumor necrosis factor (TNF)-α and interleukin (IL)-10, and whether serum SP levels during the first week could be used as a biomarker of sepsis mortality. We determined serum concentration of SP, TNF-α, and IL-10 at days 1, 4, and 8. The end-point of the study was mortality at 30 days. We found that on-survivor ( = 104) compared to survivor patients ( = 206) showed lower serum SP levels at days 1, 4, and 8 ( 0.001). Multiple logistic regression analyses showed an association between 30-day mortality and serum SP levels at days 1, 4, and 8 ( < 0.001) controlling for SOFA score, diabetes mellitus, age, and lactic acid levels. The most interesting findings of our study were that there is an association between serum SP levels during the first week and sepsis mortality, and that serum SP levels during the first week could be used as a biomarker of sepsis mortality.

Citing Articles

Peripheral ischemic reserve in sepsis and septic shock as a new bedside prognostic enrichment tool: A Brazilian cohort study.

Miranda A, do Carmo De Stefani F, Vesco B, Carraro Junior H, Morello L, Assreuy J PLoS One. 2023; 18(7):e0288249.

PMID: 37406024 PMC: 10321605. DOI: 10.1371/journal.pone.0288249.

Inflammation and Organ Injury the Role of Substance P and Its Receptors.

Zhu Z, Bhatia M Int J Mol Sci. 2023; 24(7).

PMID: 37047113 PMC: 10094202. DOI: 10.3390/ijms24076140.

The prognostic value of peripheral ischemic microvascular reserve in sepsis is not related to calcitonin gene-related peptide or substance P.

Miranda A, do Carmo De Stefani F, Carraro Junior H, Luy A, Ferreira L, Morello L Rev Bras Ter Intensiva. 2022; 34(3):367-373.

PMID: 36351068 PMC: 9749096. DOI: 10.5935/0103-507X.20220102-pt.

Hydrogen Sulfide and Substance P Levels in Patients with and Bacteraemia.

Manandhar S, Scott-Thomas A, Harrington M, Sinha P, Pilbrow A, Richards A Int J Mol Sci. 2022; 23(15).

PMID: 35955767 PMC: 9368963. DOI: 10.3390/ijms23158639.

The interaction between neurokinin-1 receptors and cyclooxygenase-2 in fever genesis.

Keringer P, Rumbus Z Temperature (Austin). 2019; 6(1):4-6.

PMID: 30906808 PMC: 6422470. DOI: 10.1080/23328940.2019.1567247.

References

De Swert K, Joos G . Extending the understanding of sensory neuropeptides. Eur J Pharmacol. 2006; 533(1-3):171-81. DOI: 10.1016/j.ejphar.2005.12.066. View

Lorente L, Martin M, Almeida T, Hernandez M, Ferreres J, Sole-Violan J . Association between serum substance P levels and mortality in patients with severe sepsis. J Crit Care. 2015; 30(5):924-8. DOI: 10.1016/j.jcrc.2015.05.012. View

Lighvani S, Huang X, Trivedi P, Swanborg R, Hazlett L . Substance P regulates natural killer cell interferon-gamma production and resistance to Pseudomonas aeruginosa infection. Eur J Immunol. 2005; 35(5):1567-75. DOI: 10.1002/eji.200425902. View

Satake H, Kawada T . Overview of the primary structure, tissue-distribution, and functions of tachykinins and their receptors. Curr Drug Targets. 2006; 7(8):963-74. DOI: 10.2174/138945006778019273. View

Lorente L, Martin M, Sole-Violan J, Blanquer J, Labarta L, Diaz C . Association of sepsis-related mortality with early increase of TIMP-1/MMP-9 ratio. PLoS One. 2014; 9(4):e94318. PMC: 3984125. DOI: 10.1371/journal.pone.0094318. View

Yang S, Stepien D, Hanseman D, Robinson B, Goodman M, Pritts T . Substance P mediates reduced pneumonia rates after traumatic brain injury. Crit Care Med. 2014; 42(9):2092-100. PMC: 4215933. DOI: 10.1097/CCM.0000000000000486. View

Lorente L, Martin M, Lopez-Gallardo E, Blanquer J, Sole-Violan J, Labarta L . Decrease of oxidative phosphorylation system function in severe septic patients. J Crit Care. 2015; 30(5):935-9. DOI: 10.1016/j.jcrc.2015.05.031. View

Maggi C . The effects of tachykinins on inflammatory and immune cells. Regul Pept. 1997; 70(2-3):75-90. DOI: 10.1016/s0167-0115(97)00029-3. View

Beer S, Weighardt H, Emmanuilidis K, Harzenetter M, Matevossian E, Heidecke C . Systemic neuropeptide levels as predictive indicators for lethal outcome in patients with postoperative sepsis. Crit Care Med. 2002; 30(8):1794-8. DOI: 10.1097/00003246-200208000-00020. View

10.

Pennefather J, Lecci A, Candenas M, Patak E, Pinto F, Maggi C . Tachykinins and tachykinin receptors: a growing family. Life Sci. 2004; 74(12):1445-63. DOI: 10.1016/j.lfs.2003.09.039. View

11.

Lorente L, Martin M, Perez-Cejas A, Lopez R, Ferreres J, Sole-Violan J . Higher serum caspase-cleaved cytokeratin-18 levels during the first week of sepsis diagnosis in non-survivor patients. Clin Chem Lab Med. 2017; 55(10):1621-1629. DOI: 10.1515/cclm-2016-1034. View

12.

Arnalich F, Sanchez J, Martinez M, Jimenez M, Lopez J, Vazquez J . Changes in plasma concentrations of vasoactive neuropeptides in patients with sepsis and septic shock. Life Sci. 1995; 56(2):75-81. DOI: 10.1016/0024-3205(94)00416-p. View

13.

Mashaghi A, Marmalidou A, Tehrani M, Grace P, Pothoulakis C, Dana R . Neuropeptide substance P and the immune response. Cell Mol Life Sci. 2016; 73(22):4249-4264. PMC: 5056132. DOI: 10.1007/s00018-016-2293-z. View

14.

Levy M, Fink M, Marshall J, Abraham E, Angus D, Cook D . 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Intensive Care Med. 2003; 29(4):530-8. DOI: 10.1007/s00134-003-1662-x. View

15.

Bodkin J, Fernandes E . TRPV1 and SP: key elements for sepsis outcome?. Br J Pharmacol. 2012; 170(7):1279-92. PMC: 3838676. DOI: 10.1111/bph.12056. View

16.

Ansel J, Brown J, Payan D, Brown M . Substance P selectively activates TNF-alpha gene expression in murine mast cells. J Immunol. 1993; 150(10):4478-85. View

17.

Vincent J, Sakr Y, Sprung C, Ranieri V, Reinhart K, Gerlach H . Sepsis in European intensive care units: results of the SOAP study. Crit Care Med. 2006; 34(2):344-53. DOI: 10.1097/01.ccm.0000194725.48928.3a. View

18.

Angus D, Lidicker J, Clermont G, Carcillo J, Pinsky M . Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med. 2001; 29(7):1303-10. DOI: 10.1097/00003246-200107000-00002. View

19.

Lotz M, Vaughan J, Carson D . Effect of neuropeptides on production of inflammatory cytokines by human monocytes. Science. 1988; 241(4870):1218-21. DOI: 10.1126/science.2457950. View

20.

Steinhoff M, von Mentzer B, Geppetti P, Pothoulakis C, Bunnett N . Tachykinins and their receptors: contributions to physiological control and the mechanisms of disease. Physiol Rev. 2014; 94(1):265-301. PMC: 3929113. DOI: 10.1152/physrev.00031.2013. View