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Multifaceted Roles of Extracellular RNAs in Different Diseases

Overview
Journal Mil Med Res
Publisher Biomed Central
Specialty Emergency Medicine
Date 2022 Aug 10
PMID 35948986
Authors
Affiliations
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Abstract

Extracellular RNAs (exRNAs) are novel circulating factors that can be used as biomarkers in various diseases. Their unique and diverse kinds, as well as their role as biomarkers, make them significant biomarkers. There has been immense work carried out since the discovery of exRNAs in circulation and other biological fluids to catalog and determine whether exRNAs may be utilized as indicators for health and illness. In this review, we aim to understand the current state of exRNAs in relation to various diseases and their potential as biomarkers. We will also review current issues and challenges faced in using exRNAs, with clinical and lab trials, that can be used as viable markers for different diseases.

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References
1.
Migita K, Komori A, Kozuru H, Jiuchi Y, Nakamura M, Yasunami M . Circulating microRNA Profiles in Patients with Type-1 Autoimmune Hepatitis. PLoS One. 2015; 10(11):e0136908. PMC: 4648542. DOI: 10.1371/journal.pone.0136908. View

2.
Nik Mohamed Kamal N, Shima Shahidan W . Non-Exosomal and Exosomal Circulatory MicroRNAs: Which Are More Valid as Biomarkers?. Front Pharmacol. 2020; 10:1500. PMC: 6984169. DOI: 10.3389/fphar.2019.01500. View

3.
Sundararajan V, Sarkar F, Ramasamy T . The multifaceted role of exosomes in cancer progression: diagnostic and therapeutic implications [corrected]. Cell Oncol (Dordr). 2018; 41(3):223-252. DOI: 10.1007/s13402-018-0378-4. View

4.
Kosaka N, Iguchi H, Yoshioka Y, Takeshita F, Matsuki Y, Ochiya T . Secretory mechanisms and intercellular transfer of microRNAs in living cells. J Biol Chem. 2010; 285(23):17442-52. PMC: 2878508. DOI: 10.1074/jbc.M110.107821. View

5.
Sadik N, Cruz L, Gurtner A, Rodosthenous R, Dusoswa S, Ziegler O . Extracellular RNAs: A New Awareness of Old Perspectives. Methods Mol Biol. 2018; 1740:1-15. PMC: 6509047. DOI: 10.1007/978-1-4939-7652-2_1. View