Extracellular RNAs: A New Awareness of Old Perspectives

Overview

Journal Methods Mol Biol

Specialty Molecular Biology

Date 2018 Feb 2

PMID 29388131

Citations 42

Authors

Noah Sadik

Lilian Cruz

Alessandra Gurtner

Rodosthenis S Rodosthenous

Sophie A Dusoswa

Olivia Ziegler

Thomas Sebastiaan Van Solinge

Zhiyun Wei

Ane Miren Salvador-Garicano

Bence Gyorgy

Marike Broekman

Leonora Balaj

Affiliations

Soon will be listed here.

Abstract

Extracellular RNA (exRNA) has recently expanded as a highly important area of study in biomarker discovery and cancer therapeutics. exRNA consists of diverse RNA subpopulations that are normally protected from degradation by incorporation into membranous vesicles or by lipid/protein association. They are found circulating in biofluids, and have proven highly promising for minimally invasive diagnostic and prognostic purposes, particularly in oncology. Recent work has made progress in our understanding of exRNAs-from their biogenesis, compartmentalization, and vesicle packaging to their various applications as biomarkers and therapeutics, as well as the new challenges that arise in isolation and purification for accurate and reproducible analysis. Here we review the most recent advancements in exRNA research.

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