Prediction of the Mechanism of Action of Catechin As Superoxide Anion Antioxidants and Natural Antivirals for COVID-19 Infection with Study

Overview

Journal J Adv Pharm Technol Res

Date 2022 Aug 8

PMID 35935692

Authors

Achmad Zainuddin

Ika Wiani Hidayat

Dikdik Kurnia

Zenika Febian Ramadhanty

Rizal Padilah

Affiliations

Soon will be listed here.

Abstract

Coronavirus disease-2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus-2 attacking the lungs, which contain the most oxygen. The involvement of oxidative stress in the body and the role of antioxidant compounds, namely catechins, are thought to be able to prevent various diseases, including the COVID-19 infection virus. An approach was employed between the catechins and the protein NADPH oxidase (Nox), followed by the coronavirus protease protein, to limit the generation of reactive oxygen species. This research using the method seeks to predict the mechanism of action of catechin as a superoxide radical anion inhibitor and as an antiviral for COVID-19. This study carried out molecular docking simulations of catechin compounds against Nox and coronavirus proteases and then compared them with positive controls GKT136901 and remdesivir. The binding energy of catechin and Nox in a docking simulation is - 8.30 kcal/mol, which is somewhat lower than GKT136901's binding value of - 8.72 kcal/mol. Catechin and coronavirus proteases had binding energy of - 7.89 kcal/mol, which was greater than remdesivir's binding energy of - 7.50 kcal/mol. Based on data, catechin as an antioxidant compound can be antiviral for COVID-19.

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