Role of Oxidative Stress on SARS-CoV (SARS) and SARS-CoV-2 (COVID-19) Infection: A Review

Overview

Journal Protein J

Publisher Springer

Specialty Biochemistry

Date 2020 Oct 27

PMID 33106987

Citations 156

Authors

Shanzay Suhail

Jonathan Zajac

Carl Fossum

Harrison Lowater

Cailin McCracken

Nathaniel Severson

Bethany Laatsch

Alex Narkiewicz-Jodko

Benjamin Johnson

Jessica Liebau

Sudeep Bhattacharyya

Sanchita Hati

Affiliations

Soon will be listed here.

Abstract

Novel coronavirus disease 2019 (COVID-19) has resulted in a global pandemic and is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Several studies have suggested that a precise disulfide-thiol balance is crucial for viral entry and fusion into the host cell and that oxidative stress generated from free radicals can affect this balance. Here, we reviewed the current knowledge about the role of oxidative stress on SARS-CoV and SARS-CoV-2 infections. We focused on the impact of antioxidants, like NADPH and glutathione, and redox proteins, such as thioredoxin and protein disulfide isomerase, that maintain the disulfide-thiol balance in the cell. The possible influence of these biomolecules on the binding of viral protein with the host cell angiotensin-converting enzyme II receptor protein as well as on the severity of COVID-19 infection was discussed.

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