Harnessing the Full Potential of Extracellular Vesicles As Drug Carriers

Overview

Journal Curr Opin Colloid Interface Sci

Publisher Current Science

Specialty Chemistry

Date 2022 Aug 8

PMID 35935265

Authors

Natalie Jasiewicz

Corinne Drabenstott

Juliane Nguyen

Affiliations

Soon will be listed here.

Abstract

Extracellular vesicles are natural delivery systems widely implicated in cellular communication. However, to fully utilize these vehicles as nanocarriers, we must explore various methods to modify their applicability as drug delivery vehicles. In this review, we outline and discuss techniques to engineer extracellular vehicles for enhanced loading, targeting, circulation, and tracking. We highlight cutting-edge methods to amplify extracellular vesicle secretion and production and optimize storage conditions to improve their clinical suitability. Moreover, we focus on reverse engineering as an important step in controlling their biological function. By taking a reductionist approach to characterize and understand the individual components of these carriers, we can not only elucidate complex mechanisms of action but also advance the field through the creation of synthetic drug delivery vehicles. Finally, we propose current challenges and future directions of the field.

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