High Endothelial Venules As Potential Gateways for Therapeutics

Overview

Journal Trends Immunol

Specialty Allergy & Immunology

Date 2022 Aug 5

PMID 35931612

Authors

Bilal Hussain

Vivek Kasinath

Gabriel P Ashton-Rickardt

Thomas Clancy

Kenji Uchimura

George Tsokos

Reza Abdi

Affiliations

Soon will be listed here.

Abstract

High endothelial venules (HEVs) are specialized blood vessels that support the migration of lymphocytes from the bloodstream into lymph nodes (LNs). They are also formed ectopically in mammalian organs affected by chronic inflammation and cancer. The recent arrival of immunotherapy at the forefront of many cancer treatment regimens could boost a crucial role for HEVs as gateways for the treatment of cancer. In this review, we describe the microanatomical and biochemical characteristics of HEVs, mechanisms of formation of newly made HEVs, immunotherapies potentially dependent on HEV-mediated T cell homing to tumors, and finally, how HEV-targeted therapies might be used as a complementary approach to potentially shape the therapeutic landscape for the treatment of cancer and immune-mediated diseases.

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