High COL10A1 Expression Potentially Contributes to Poor Outcomes in Gastric Cancer with the Help of LEF1 and Wnt2

Overview

Journal J Clin Lab Anal

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
Pathology

Date 2022 Aug 5

PMID 35929139

Authors

Miaozun Zhang

Ming Jin

Zhiqiang Gao

Weiming Yu

Wei Zhang

Affiliations

Soon will be listed here.

Abstract

Background: COL10A1 is a secreted, short-chain collagen found in several types of cancer. Studies have shown that COL10A1 aberrant expression is considered an oncogenic factor. However, its underlying mechanisms and regulation of gastric cancer remain undefined.

Methods: The data on the expression of COL10A1, clinicopathological characteristics, and outcome of patients with GC were obtained from The Cancer Genome Atlas. The ALGGEN-PROMO database defined the related transcription factors. Quantitative real-time reverse transcription-polymerase chain reaction and western blotting analysis were used to identify the differential expression levels of COL10A1 and related transcription factors.

Results: We found that high COL10A1 expression is an independent risk factor for gastric cancer. Upregulation of LEF1 and Wnt2 was also observed in gastric cancer, suggesting a potential correlation between LEF1/COL10A1 regulation in the Wnt2 signaling pathway.

Conclusion: High COL10A1 expression may contribute to poor outcomes via upregulation of LEF1 and Wnt2 in gastric cancer.

Citing Articles

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High COL10A1 expression potentially contributes to poor outcomes in gastric cancer with the help of LEF1 and Wnt2.

Zhang M, Jin M, Gao Z, Yu W, Zhang W J Clin Lab Anal. 2022; 36(9):e24612.

PMID: 35929139 PMC: 9459277. DOI: 10.1002/jcla.24612.

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