Synthesis and Biological Evaluation of 3-(Pyridine-3-yl)-2-Oxazolidinone Derivatives As Antibacterial Agents

Overview

Journal Front Chem

Specialty Chemistry

Date 2022 Aug 4

PMID 35923260

Authors

Bo Jin

Tong Wang

Jia-Yi Chen

Xiao-Qing Liu

Yi-Xin Zhang

Xiu-Ying Zhang

Zun-Lai Sheng

Hong-Liang Yang

Affiliations

Soon will be listed here.

Abstract

In this research, a series of 3-(pyridine-3-yl)-2-oxazolidinone derivatives was designed, synthesized, and evaluated for antibacterial activity, which included bacteriostatic, morphological, kinetic studies, and molecular docking. The results demonstrated that compounds , , and exhibited strong antibacterial activity similar to that of linezolid toward five Gram-positive bacteria. After observing the effect of the drug on the morphology and growth dynamics of the bacteria, the possible modes of action were predicted by molecular docking. Furthermore, the antibiofilm activity and the potential drug resistance assay was proceeded. These compounds exhibited universal antibiofilm activity and compound showed significant concentration-dependent inhibition of biofilm formation. Compound also showed a stable effect on (ATCC 49619) with less drug resistance growth for 15 days, which is much longer than that of linezolid. Overall, these results can be used to guide further exploration of novel antimicrobial agents.

Citing Articles

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