[Cu]Cu-ATSM: an Emerging Theranostic Agent for Cancer and Neuroinflammation

Overview

Journal Eur J Nucl Med Mol Imaging

Specialties Biophysics
Nuclear Medicine
Radiology

Date 2022 Aug 2

PMID 35918492

Authors

Fang Xie

Weijun Wei

Affiliations

Soon will be listed here.

Citing Articles

Relationship between renal oxidative stress levels and disease severity in patients with chronic kidney disease assessed by [Cu-64]ATSM PET/MRI.

Huang Y, Nishikawa Y, Mori T, Nogami M, Makino A, Kiyono Y Sci Rep. 2025; 15(1):7227.

PMID: 40021767 PMC: 11871321. DOI: 10.1038/s41598-024-85027-2.

Bifunctional Copper Chelators Capable of Reducing Aβ Aggregation and Aβ-Induced Oxidative Stress.

Krasnovskaya O, Abramchuk D, Vaneev A, Gorelkin P, Abakumov M, Timoshenko R ACS Omega. 2024; 9(43):43376-43384.

PMID: 39493999 PMC: 11525521. DOI: 10.1021/acsomega.4c03152.

Biomarker-driven molecular imaging probes in radiotherapy.

Li H, Gong Q, Luo K Theranostics. 2024; 14(10):4127-4146.

PMID: 38994026 PMC: 11234278. DOI: 10.7150/thno.97768.

Unveiling the promising anticancer effect of copper-based compounds: a comprehensive review.

Abdolmaleki S, Aliabadi A, Khaksar S J Cancer Res Clin Oncol. 2024; 150(4):213.

PMID: 38662225 PMC: 11045632. DOI: 10.1007/s00432-024-05641-5.

A Luciferase Reporter Assay to Detect Cellular Hypoxia In Vitro.

Inubushi M, Takeuchi Y, Murai C, Kitagawa Y Methods Mol Biol. 2024; 2755:77-89.

PMID: 38319570 DOI: 10.1007/978-1-0716-3633-6_5.

References

Kreisl W, Kim M, Coughlin J, Henter I, Owen D, Innis R . PET imaging of neuroinflammation in neurological disorders. Lancet Neurol. 2020; 19(11):940-950. PMC: 7912433. DOI: 10.1016/S1474-4422(20)30346-X. View

Wu C, Li F, Niu G, Chen X . PET imaging of inflammation biomarkers. Theranostics. 2013; 3(7):448-66. PMC: 3706689. DOI: 10.7150/thno.6592. View

Zhang L, Hu K, Shao T, Hou L, Zhang S, Ye W . Recent developments on PET radiotracers for TSPO and their applications in neuroimaging. Acta Pharm Sin B. 2021; 11(2):373-393. PMC: 7893127. DOI: 10.1016/j.apsb.2020.08.006. View

Tai Y, Pavese N, Gerhard A, Tabrizi S, Barker R, Brooks D . Imaging microglial activation in Huntington's disease. Brain Res Bull. 2007; 72(2-3):148-51. DOI: 10.1016/j.brainresbull.2006.10.029. View

Weissman B, Raveh L . Peripheral benzodiazepine receptors: on mice and human brain imaging. J Neurochem. 2003; 84(3):432-7. DOI: 10.1046/j.1471-4159.2003.01568.x. View

Bartels A, Willemsen A, Doorduin J, de Vries E, Dierckx R, Leenders K . [11C]-PK11195 PET: quantification of neuroinflammation and a monitor of anti-inflammatory treatment in Parkinson's disease?. Parkinsonism Relat Disord. 2009; 16(1):57-9. DOI: 10.1016/j.parkreldis.2009.05.005. View

Venneti S, Lopresti B, Wang G, Hamilton R, Mathis C, Klunk W . PK11195 labels activated microglia in Alzheimer's disease and in vivo in a mouse model using PET. Neurobiol Aging. 2008; 30(8):1217-26. PMC: 2745919. DOI: 10.1016/j.neurobiolaging.2007.11.005. View

Schubert J, Tonietto M, Turkheimer F, Zanotti-Fregonara P, Veronese M . Supervised clustering for TSPO PET imaging. Eur J Nucl Med Mol Imaging. 2021; 49(1):257-268. PMC: 8712290. DOI: 10.1007/s00259-021-05309-z. View

Unterrainer M, Mahler C, Vomacka L, Lindner S, Havla J, Brendel M . TSPO PET with [F]GE-180 sensitively detects focal neuroinflammation in patients with relapsing-remitting multiple sclerosis. Eur J Nucl Med Mol Imaging. 2018; 45(8):1423-1431. DOI: 10.1007/s00259-018-3974-7. View

10.

Vomacka L, Albert N, Lindner S, Unterrainer M, Mahler C, Brendel M . TSPO imaging using the novel PET ligand [F]GE-180: quantification approaches in patients with multiple sclerosis. EJNMMI Res. 2017; 7(1):89. PMC: 5693838. DOI: 10.1186/s13550-017-0340-x. View

11.

Albert N, Unterrainer M, Fleischmann D, Lindner S, Vettermann F, Brunegraf A . TSPO PET for glioma imaging using the novel ligand F-GE-180: first results in patients with glioblastoma. Eur J Nucl Med Mol Imaging. 2017; 44(13):2230-2238. DOI: 10.1007/s00259-017-3799-9. View

12.

Pascoal T, Benedet A, Ashton N, Kang M, Therriault J, Chamoun M . Microglial activation and tau propagate jointly across Braak stages. Nat Med. 2021; 27(9):1592-1599. DOI: 10.1038/s41591-021-01456-w. View

13.

Plastini M, Desu H, Brambilla R . Dynamic Responses of Microglia in Animal Models of Multiple Sclerosis. Front Cell Neurosci. 2020; 14:269. PMC: 7468479. DOI: 10.3389/fncel.2020.00269. View

14.

Hagens M, Golla S, Wijburg M, Yaqub M, Heijtel D, Steenwijk M . In vivo assessment of neuroinflammation in progressive multiple sclerosis: a proof of concept study with [F]DPA714 PET. J Neuroinflammation. 2018; 15(1):314. PMC: 6234549. DOI: 10.1186/s12974-018-1352-9. View

15.

Beaino W, Janssen B, Kooij G, van der Pol S, van het Hof B, van Horssen J . Purinergic receptors P2Y12R and P2X7R: potential targets for PET imaging of microglia phenotypes in multiple sclerosis. J Neuroinflammation. 2017; 14(1):259. PMC: 5741931. DOI: 10.1186/s12974-017-1034-z. View

16.

Van Weehaeghe D, Koole M, Schmidt M, Deman S, Jacobs A, Souche E . [C]JNJ54173717, a novel P2X7 receptor radioligand as marker for neuroinflammation: human biodistribution, dosimetry, brain kinetic modelling and quantification of brain P2X7 receptors in patients with Parkinson's disease and healthy volunteers. Eur J Nucl Med Mol Imaging. 2019; 46(10):2051-2064. DOI: 10.1007/s00259-019-04369-6. View

17.

van der Wildt B, Janssen B, Pekosak A, Steen E, Schuit R, Kooijman E . Novel Thienopyrimidine-Based PET Tracers for P2Y Receptor Imaging in the Brain. ACS Chem Neurosci. 2021; 12(23):4465-4474. PMC: 8640995. DOI: 10.1021/acschemneuro.1c00641. View

18.

Tada M, Konno T, Tada M, Tezuka T, Miura T, Mezaki N . Characteristic microglial features in patients with hereditary diffuse leukoencephalopathy with spheroids. Ann Neurol. 2016; 80(4):554-65. DOI: 10.1002/ana.24754. View

19.

Rademakers R, Baker M, Nicholson A, Rutherford N, Finch N, Soto-Ortolaza A . Mutations in the colony stimulating factor 1 receptor (CSF1R) gene cause hereditary diffuse leukoencephalopathy with spheroids. Nat Genet. 2011; 44(2):200-5. PMC: 3267847. DOI: 10.1038/ng.1027. View

20.

Horti A, Naik R, Foss C, Minn I, Misheneva V, Du Y . PET imaging of microglia by targeting macrophage colony-stimulating factor 1 receptor (CSF1R). Proc Natl Acad Sci U S A. 2019; 116(5):1686-1691. PMC: 6358677. DOI: 10.1073/pnas.1812155116. View