Necroptosis Pathways in Tumorigenesis

Overview

Journal Semin Cancer Biol

Specialty Oncology

Date 2022 Jul 31

PMID 35908574

Authors

Tao Zhang

Yingnan Wang

Hiroyuki Inuzuka

Wenyi Wei

Affiliations

Soon will be listed here.

Abstract

Necroptosis is a caspase-independent form of programmed cell death executed by the receptor interacting protein kinase 1 (RIPK1)-RIPK3-mixed lineage kinase domain-like protein (MLKL) signaling cascade, deregulation of which can cause various human diseases including cancer. Escape from programmed cell death is a hallmark of cancer, leading to uncontrolled growth and drug resistance. Therefore, it is crucial to further understand whether necroptosis plays a key role in therapeutic resistance. In this review, we summarize the recent findings of the link between necroptosis and cancer, and discuss that targeting necroptosis is a new strategy to overcome apoptosis resistance in tumor therapy.

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