A Novel Polysaccharide From Displays Hypoglycemic Activity in a Diabetic Mouse Model

Overview

Journal Front Nutr

Specialty Nutritional Sciences

Date 2022 Jul 28

PMID 35898716

Authors

Xiaobin Feng

Peng Wang

Yuxiao Lu

Zejun Zhang

Chunxin Yao

Guoting Tian

Qinghong Liu

Affiliations

Soon will be listed here.

Abstract

A novel polysaccharide, Polysaccharide (HRP) was extracted from the edible mushroom . HRP had weight-average molecular weight 1,949 kDa and number-average molecular weight 873 kDa, and its major components were arabinose (0.71%), galactose (12.93%), glucose (49.00%), xylose (8.59%), mannose (17.78%), and glucuronic acid (10.99%). Fourier transform infrared spectroscopy and nuclear magnetic resonance spectroscopy revealed that HRP was composed of 1,3-linked β-D-glucose, 1,6-linked β-D-mannose, 1,6-linked β-D-galactose, 1,4-linked β-D-galactose, 1,4-linked β-D-xylose, and 1,5-linked α-L-arabinose. Thermogravimetric analysis indicated that degradation temperature (T) of HRP was 200°C. In an STZ-induced diabetic mouse model, oral administration of HRP (40 mg/kg/d) for 28 days significantly reduced blood glucose levels, and reduced heart organ index by decreasing expression of IL-6 and TNF-α. Our findings indicate hypoglycemic effect of HRP, and its potential application as a hypoglycemic agent.

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