Different Roles of Dendritic Cells for Chronic Rhinosinusitis Treatment According to Phenotype

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2022 Jul 27

PMID 35887379

Authors

Junhu Tai

Jiwon Kwak

Munsoo Han

Tae Hoon Kim

Affiliations

Soon will be listed here.

Abstract

Dendritic cells (DCs) are antigen-presenting cells derived from the bone marrow that play an important role in the association between the innate and adaptive immune responses. The onset and development of chronic rhinosinusitis (CRS) involve a serious imbalance in immune regulation and mechanical dysfunction caused by an abnormal remodeling process. Recent studies have shown that an increase in DCs in CRS and their function of shaping the nasal mucosal immune response may play an important role in the pathogenesis of CRS. In this review, we discuss DC subsets in mice and humans, as well as the function of DCs in the nasal sinus mucosa. In addition, the mechanism by which DCs can be used as targets for therapeutic intervention for CRS and potential future research directions are also discussed.

Citing Articles

Dendritic cell immunometabolism - a potential therapeutic target for allergic diseases.

Ouyang C, Huang J, Huang G, Wang Y Int J Med Sci. 2025; 22(2):417-431.

PMID: 39781535 PMC: 11704690. DOI: 10.7150/ijms.105532.

Pathogenesis, Diagnosis, and Treatment of Infectious Rhinosinusitis.

Huang F, Liu F, Zhen X, Gong S, Chen W, Song Z Microorganisms. 2024; 12(8).

PMID: 39203531 PMC: 11357447. DOI: 10.3390/microorganisms12081690.

References

Spranger S, Dai D, Horton B, Gajewski T . Tumor-Residing Batf3 Dendritic Cells Are Required for Effector T Cell Trafficking and Adoptive T Cell Therapy. Cancer Cell. 2017; 31(5):711-723.e4. PMC: 5650691. DOI: 10.1016/j.ccell.2017.04.003. View

Holgate S, Bodey K, JANEZIC A, Frew A, Kaplan A, Teran L . Release of RANTES, MIP-1 alpha, and MCP-1 into asthmatic airways following endobronchial allergen challenge. Am J Respir Crit Care Med. 1997; 156(5):1377-83. DOI: 10.1164/ajrccm.156.5.9610064. View

Kirsche H, Niederfuhr A, Deutschle T, Fuchs C, Riechelmann H . Ratio of myeloid and plasmacytoid dendritic cells and TH2 skew in CRS with nasal polyps. Allergy. 2009; 65(1):24-31. DOI: 10.1111/j.1398-9995.2009.02174.x. View

Ballesteros-Tato A, Leon B, Lund F, Randall T . Temporal changes in dendritic cell subsets, cross-priming and costimulation via CD70 control CD8(+) T cell responses to influenza. Nat Immunol. 2010; 11(3):216-24. PMC: 2822886. DOI: 10.1038/ni.1838. View

Gu L, Tseng S, Horner R, Tam C, Loda M, Rollins B . Control of TH2 polarization by the chemokine monocyte chemoattractant protein-1. Nature. 2000; 404(6776):407-11. DOI: 10.1038/35006097. View

Liu T, Li T, Zhao F, Xie C, Liu A, Chen X . Role of thymic stromal lymphopoietin in the pathogenesis of nasal polyposis. Am J Med Sci. 2010; 341(1):40-7. DOI: 10.1097/MAJ.0b013e3181f20489. View

Tak P, Balanescu A, Tseluyko V, Bojin S, Drescher E, Dairaghi D . Chemokine receptor CCR1 antagonist CCX354-C treatment for rheumatoid arthritis: CARAT-2, a randomised, placebo controlled clinical trial. Ann Rheum Dis. 2012; 72(3):337-44. DOI: 10.1136/annrheumdis-2011-201605. View

Leon B, Lopez-Bravo M, Ardavin C . Monocyte-derived dendritic cells formed at the infection site control the induction of protective T helper 1 responses against Leishmania. Immunity. 2007; 26(4):519-31. DOI: 10.1016/j.immuni.2007.01.017. View

Pothoven K, Norton J, Suh L, Carter R, Harris K, Biyasheva A . Neutrophils are a major source of the epithelial barrier disrupting cytokine oncostatin M in patients with mucosal airways disease. J Allergy Clin Immunol. 2016; 139(6):1966-1978.e9. PMC: 5529124. DOI: 10.1016/j.jaci.2016.10.039. View

10.

Davison A, King N . Accelerated dendritic cell differentiation from migrating Ly6C(lo) bone marrow monocytes in early dermal West Nile virus infection. J Immunol. 2011; 186(4):2382-96. DOI: 10.4049/jimmunol.1002682. View

11.

Shi L, Song J, Xiong P, Cao P, Liao B, Ma J . Disease-specific T-helper cell polarizing function of lesional dendritic cells in different types of chronic rhinosinusitis with nasal polyps. Am J Respir Crit Care Med. 2014; 190(6):628-38. DOI: 10.1164/rccm.201402-0234OC. View

12.

Segura E, Valladeau-Guilemond J, Donnadieu M, Sastre-Garau X, Soumelis V, Amigorena S . Characterization of resident and migratory dendritic cells in human lymph nodes. J Exp Med. 2012; 209(4):653-60. PMC: 3328358. DOI: 10.1084/jem.20111457. View

13.

Wang X, Gao M, Xu Y, Guo H, Zhao C . Expression of interleukin-22 and its significance in the pathogenesis of chronic rhinosinusitis. Int J Clin Exp Pathol. 2014; 7(9):5709-16. PMC: 4203183. View

14.

Annunziato F, Romagnani C, Romagnani S . The 3 major types of innate and adaptive cell-mediated effector immunity. J Allergy Clin Immunol. 2014; 135(3):626-35. DOI: 10.1016/j.jaci.2014.11.001. View

15.

Valladeau J, Ravel O, Dezutter-Dambuyant C, Moore K, Kleijmeer M, Liu Y . Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules. Immunity. 2000; 12(1):71-81. DOI: 10.1016/s1074-7613(00)80160-0. View

16.

Giavina-Bianchi P, Aun M, Takejima P, Kalil J, Agondi R . United airway disease: current perspectives. J Asthma Allergy. 2016; 9:93-100. PMC: 4872272. DOI: 10.2147/JAA.S81541. View

17.

Cheong C, Matos I, Choi J, Dandamudi D, Shrestha E, Longhi M . Microbial stimulation fully differentiates monocytes to DC-SIGN/CD209(+) dendritic cells for immune T cell areas. Cell. 2010; 143(3):416-29. PMC: 3150728. DOI: 10.1016/j.cell.2010.09.039. View

18.

Cho S, Hamilos D, Han D, Laidlaw T . Phenotypes of Chronic Rhinosinusitis. J Allergy Clin Immunol Pract. 2020; 8(5):1505-1511. PMC: 7696652. DOI: 10.1016/j.jaip.2019.12.021. View

19.

Perez-Novo C, Pezato R . Dendritic cell subset expression in severe chronic rhinosinusitis with nasal polyps. Curr Opin Allergy Clin Immunol. 2016; 17(1):1-4. DOI: 10.1097/ACI.0000000000000328. View

20.

Reis e Sousa C . Activation of dendritic cells: translating innate into adaptive immunity. Curr Opin Immunol. 2004; 16(1):21-5. DOI: 10.1016/j.coi.2003.11.007. View