MiRNAs in Lung Cancer: Diagnostic, Prognostic, and Therapeutic Potential

Overview

Journal Diagnostics (Basel)

Specialty Radiology

Date 2022 Jul 27

PMID 35885514

Authors

Javaid Ahmad Wani

Sabhiya Majid

Zuha Imtiyaz

Muneeb U Rehman

Rana M Alsaffar

Naveed Nazir Shah

Sultan Alshehri

Mohammed M Ghoneim

Syed Sarim Imam

Affiliations

Soon will be listed here.

Abstract

Lung cancer is the dominant emerging factor in cancer-related mortality around the globe. Therapeutic interventions for lung cancer are not up to par, mainly due to reoccurrence/relapse, chemoresistance, and late diagnosis. People are currently interested in miRNAs, which are small double-stranded (20-24 ribonucleotides) structures that regulate molecular targets (tumor suppressors, oncogenes) involved in tumorigeneses such as cell proliferation, apoptosis, metastasis, and angiogenesis via post-transcriptional regulation of mRNA. Many studies suggest the emerging role of miRNAs in lung cancer diagnostics, prognostics, and therapeutics. Therefore, it is necessary to intensely explore the miRNOME expression of lung tumors and the development of anti-cancer strategies. The current review focuses on the therapeutic, diagnostic, and prognostic potential of numerous miRNAs in lung cancer.

Citing Articles

Prognostic Value of miR-10a-3p in Non-Small Cell Lung Cancer Patients.

Simiene J, Kunigenas L, Prokarenkaite R, Dabkeviciene D, Strainiene E, Stankevicius V Onco Targets Ther. 2024; 17:1017-1032.

PMID: 39559728 PMC: 11572442. DOI: 10.2147/OTT.S475644.

Harmonising cellular conversations: decoding the vital roles of extracellular vesicles in respiratory system intercellular communications.

Jadamba B, Jin Y, Lee H Eur Respir Rev. 2024; 33(174).

PMID: 39537245 PMC: 11558538. DOI: 10.1183/16000617.0272-2023.

miR-127/3p Inhibits Cell Migration in Lung Adenocarcinoma Under Hypoxic and Normal Oxygen Conditions.

Lipscomb J, Gray K, Melton T, Nelson P, Rye A, Pruett C MicroPubl Biol. 2024; 2024.

PMID: 39483961 PMC: 11525482. DOI: 10.17912/micropub.biology.001355.

Research progress on the mechanism of exosome-mediated virus infection.

Zhang H, Liu X, Shi J, Su X, Xie J, Meng Q Front Cell Infect Microbiol. 2024; 14:1418168.

PMID: 38988816 PMC: 11233549. DOI: 10.3389/fcimb.2024.1418168.

Screening and analysis of single nucleotide polymorphism in the 3'-UTR microRNA target regions and its implications for lung tumorigenesis.

Bhatia A, Upadhyay A, Sharma S Pharmacogenomics. 2024; 25(7):299-314.

PMID: 38884942 PMC: 11404702. DOI: 10.1080/14622416.2024.2355864.

References

Sun Y, Hawkins P, Bi N, Dess R, Tewari M, Hearn J . Serum MicroRNA Signature Predicts Response to High-Dose Radiation Therapy in Locally Advanced Non-Small Cell Lung Cancer. Int J Radiat Oncol Biol Phys. 2017; 100(1):107-114. PMC: 5736451. DOI: 10.1016/j.ijrobp.2017.08.039. View

Kim E, Kim J, Lee S, Lee H, Yoon J, Hong J . QKI, a miR-200 target gene, suppresses epithelial-to-mesenchymal transition and tumor growth. Int J Cancer. 2019; 145(6):1585-1595. DOI: 10.1002/ijc.32372. View

Watashi K, Yeung M, Starost M, Hosmane R, Jeang K . Identification of small molecules that suppress microRNA function and reverse tumorigenesis. J Biol Chem. 2010; 285(32):24707-16. PMC: 2915707. DOI: 10.1074/jbc.M109.062976. View

Lin L, Tu H, Wu L, Liu M, Jiang G . MicroRNA-21 Regulates Non-Small Cell Lung Cancer Cell Invasion and Chemo-Sensitivity through SMAD7. Cell Physiol Biochem. 2016; 38(6):2152-62. DOI: 10.1159/000445571. View

Vaupel P, Mayer A . Hypoxia in cancer: significance and impact on clinical outcome. Cancer Metastasis Rev. 2007; 26(2):225-39. DOI: 10.1007/s10555-007-9055-1. View

Shao L, Lu X, Zhou Y, Wang Y, Wang X, Zhuang Z . Altered miR-93-5p/miR-18a expression in serum for diagnosing non-small cell lung cancer. Am J Transl Res. 2021; 13(5):5073-5079. PMC: 8205697. View

Schreiber G, McCrory D . Performance characteristics of different modalities for diagnosis of suspected lung cancer: summary of published evidence. Chest. 2003; 123(1 Suppl):115S-128S. DOI: 10.1378/chest.123.1_suppl.115s. View

Liu J, Jia Y, Jia L, Li T, Yang L, Zhang G . MicroRNA 615-3p Inhibits the Tumor Growth and Metastasis of NSCLC via Inhibiting IGF2. Oncol Res. 2018; 27(2):269-279. PMC: 7848428. DOI: 10.3727/096504018X15215019227688. View

Chen X, Tong Z, Zhou J, Yao Y, Zhang S, Zhou J . MicroRNA-206 inhibits the viability and migration of human lung adenocarcinoma cells partly by targeting MET. Oncol Lett. 2016; 12(2):1171-1177. PMC: 4950289. DOI: 10.3892/ol.2016.4735. View

10.

Roth C, Stuckrath I, Pantel K, Izbicki J, Tachezy M, Schwarzenbach H . Low levels of cell-free circulating miR-361-3p and miR-625* as blood-based markers for discriminating malignant from benign lung tumors. PLoS One. 2012; 7(6):e38248. PMC: 3366929. DOI: 10.1371/journal.pone.0038248. View

11.

Chen X, Wu L, Li D, Xu Y, Zhang L, Niu K . Radiosensitizing effects of miR-18a-5p on lung cancer stem-like cells via downregulating both ATM and HIF-1α. Cancer Med. 2018; 7(8):3834-3847. PMC: 6089184. DOI: 10.1002/cam4.1527. View

12.

Ma W, Ma C, Li X, Zhang Y . Examining the effect of gene reduction in miR-95 and enhanced radiosensitivity in non-small cell lung cancer. Cancer Gene Ther. 2016; 23(2-3):66-71. DOI: 10.1038/cgt.2016.2. View

13.

Cao X, Lai S, Hu F, Li G, Wang G, Luo X . miR-19a contributes to gefitinib resistance and epithelial mesenchymal transition in non-small cell lung cancer cells by targeting c-Met. Sci Rep. 2017; 7(1):2939. PMC: 5462753. DOI: 10.1038/s41598-017-01153-0. View

14.

Pavel A, Campbell J, Liu G, Elashoff D, Dubinett S, Smith K . Alterations in Bronchial Airway miRNA Expression for Lung Cancer Detection. Cancer Prev Res (Phila). 2017; 10(11):651-659. PMC: 6758560. DOI: 10.1158/1940-6207.CAPR-17-0098. View

15.

Bianchi F, Nicassio F, Marzi M, Belloni E, DallOlio V, Bernard L . A serum circulating miRNA diagnostic test to identify asymptomatic high-risk individuals with early stage lung cancer. EMBO Mol Med. 2011; 3(8):495-503. PMC: 3377091. DOI: 10.1002/emmm.201100154. View

16.

Ke Y, Zhao W, Xiong J, Cao R . Downregulation of miR-16 promotes growth and motility by targeting HDGF in non-small cell lung cancer cells. FEBS Lett. 2013; 587(18):3153-7. DOI: 10.1016/j.febslet.2013.08.010. View

17.

Yu S, Chen H, Chang G, Chen C, Chen H, Singh S . MicroRNA signature predicts survival and relapse in lung cancer. Cancer Cell. 2008; 13(1):48-57. DOI: 10.1016/j.ccr.2007.12.008. View

18.

Liu H, Huang J, Peng J, Wu X, Zhang Y, Zhu W . Upregulation of the inwardly rectifying potassium channel Kir2.1 (KCNJ2) modulates multidrug resistance of small-cell lung cancer under the regulation of miR-7 and the Ras/MAPK pathway. Mol Cancer. 2015; 14:59. PMC: 4373128. DOI: 10.1186/s12943-015-0298-0. View

19.

Ergun S, Guney S, Temiz E, Petrovic N, Gunes S . Significance of miR-15a-5p and CNKSR3 as Novel Prognostic Biomarkers in Non-Small Cell Lung Cancer. Anticancer Agents Med Chem. 2018; 18(12):1695-1701. DOI: 10.2174/1871520618666180718100656. View

20.

Hanna J, Hossain G, Kocerha J . The Potential for microRNA Therapeutics and Clinical Research. Front Genet. 2019; 10:478. PMC: 6532434. DOI: 10.3389/fgene.2019.00478. View