Altered MiR-93-5p/miR-18a Expression in Serum for Diagnosing Non-small Cell Lung Cancer

Overview

Journal Am J Transl Res

Specialty General Medicine

Date 2021 Jun 21

PMID 34150094

Citations 3

Authors

Lili Shao

Xiaomin Lu

Yan Zhou

Yan Wang

Xiaoli Wang

Zhixiang Zhuang

Jun Gong

Affiliations

Soon will be listed here.

Abstract

Objective: This research aimed at probing into miR-93-5p and miR-18a's diagnostic and prognostic values in non-small cell lung cancer (NSCLC) patients.

Methods: A total of 107 patients diagnosed with NSCLC in the Department of Oncology and Thoracic Surgery of our hospital from January 2015 to June 2016 were regarded as the research group (RG), and 42 healthy people were considered as the control group (CG). Serum samples were collected and miR-93-5p, miR-18a expression was detected via qPCR. The relationship between miR-93-5p, miR-18a and clinicopathological characteristics of NSCLC patients was assessed, and the diagnostic value of the two miRNAs was analyzed by ROC curve.

Results: miR-93-5p and miR-18a were up-regulated in NSCLC. The higher the degree of tumor differentiation, the higher the TNM stage and the expression of the two miRNAs were. The high expression was tied to tumor differentiation degree, TNM stage, lymph node metastasis and lymph-vascular space invasion (LVSI). The survival rate of miR-93-5p and miR-18a high expression patients was worse than that of those with low expression. The AUC value of both of the mRNAs in NSCLC diagnosis was high (0.8905).

Conclusion: The expression of miR-93-5p and miR-18a is associated with NSCLC severity and prognosis, and both can be used as potential markers for diagnosis.

Citing Articles

Role of miR-93-5p and Its Opposing Effect of Ionizing Radiation in Non-Small Cell Lung Cancer.

Ni Q, Sang K, Zhou J, Pan C Anal Cell Pathol (Amst). 2024; 2024:4218464.

PMID: 39157415 PMC: 11330335. DOI: 10.1155/2024/4218464.

Extracellular circulating miRNAs as potential non-invasive biomarkers in non-small cell lung cancer patients.

Raczkowska J, Bielska A, Kretowski A, Niemira M Front Oncol. 2023; 13:1209299.

PMID: 37546401 PMC: 10401434. DOI: 10.3389/fonc.2023.1209299.

MiRNAs in Lung Cancer: Diagnostic, Prognostic, and Therapeutic Potential.

Wani J, Majid S, Imtiyaz Z, Rehman M, Alsaffar R, Shah N Diagnostics (Basel). 2022; 12(7).

PMID: 35885514 PMC: 9322918. DOI: 10.3390/diagnostics12071610.

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