Interaction Between Endometrial Microbiota and Host Gene Regulation in Recurrent Implantation Failure

Overview

Journal J Assist Reprod Genet

Publisher Springer

Specialties Genetics
Reproductive Medicine

Date 2022 Jul 26

PMID 35881269

Authors

Peigen Chen

Lei Jia

Yi Zhou

Yingchun Guo

Cong Fang

Tingting Li

Affiliations

Soon will be listed here.

Abstract

Aim: To learn about the interaction between endometrial microbiota and host gene regulation in recurrent implantation failure.

Methods: The endometrial microbiota of 111 patients (RIF, 75; CON, 36) was analyzed by using 16 s rRNA sequencing technology. Transcriptome sequencing analysis of the endometrial of 60 patients was performed by using high-throughput sequencing.

Results: We found that the structure and composition of endometrium microbiota community of RIF patients were significantly different from those in control group. The abnormality of microbial structure and composition might interfere with the implantation of embryos by affecting the immune adaptation of the endometrium and the formation of endometrial blood vessels.

Conclusions: Our research described the host-microbe interaction in RIF. The structure and composition of endometrium microbiota community of RIF patients were significantly different from those in CON group. The abnormality of microbial structure and composition might interfere with the implantation of embryos by affecting the immune adaptation of the endometrium and the formation of endometrial blood vessels.

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