Multi-Omics Techniques Make It Possible to Analyze Sepsis-Associated Acute Kidney Injury Comprehensively

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2022 Jul 25

PMID 35874763

Authors

Jiao Qiao

Liyan Cui

Affiliations

Soon will be listed here.

Abstract

Sepsis-associated acute kidney injury (SA-AKI) is a common complication in critically ill patients with high morbidity and mortality. SA-AKI varies considerably in disease presentation, progression, and response to treatment, highlighting the heterogeneity of the underlying biological mechanisms. In this review, we briefly describe the pathophysiology of SA-AKI, biomarkers, reference databases, and available omics techniques. Advances in omics technology allow for comprehensive analysis of SA-AKI, and the integration of multiple omics provides an opportunity to understand the information flow behind the disease. These approaches will drive a shift in current paradigms for the prevention, diagnosis, and staging and provide the renal community with significant advances in precision medicine in SA-AKI analysis.

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