X11 Ameliorates Hyperuricemia and Modulates Gut Microbiota in Mice

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2022 Jul 25

PMID 35874662

Authors

Jiayuan Cao

Qiqi Liu

Haining Hao

Yushan Bu

Xiaoying Tian

Ting Wang

Huaxi Yi

Affiliations

Soon will be listed here.

Abstract

Hyperuricemia (HUA) is the presence of excessive uric acid (UA) in blood, which leads to an increased risk of chronic kidney disease and gout. Probiotics have the potential effect of alleviating HUA. The purpose of this study was to screen probiotics with UA-lowering activity and explore the underlying mechanism. The UA-lowering activity of 20 lactic acid bacteria strains was investigated , and the effect of candidate probiotics on UA metabolism was evaluated using the HUA Balb/c mouse model. The results showed that X11 had excellent UA-lowering activity , which could degrade nucleotides and nucleosides completely within 30 min, and the degradation rates of purine and trioxypurine could reach 83.25% and 80.42%, respectively. In addition, oral administration of X11 could reduce serum UA by 52.45% and inhibit renal proinflammatory cytokine IL-1β by 50.69%, regulating adenosine deaminase (ADA), xanthine oxidase (XOD), and transporter expression (GLUT9, NPT1, and URAT1) to a normal level. Moreover, it could restore the ratio of to (Bac/Firm ratio) and showed a positive effect on the recovery of the intestinal microbiota. These findings provided fundamental information about the UA-lowering properties of probiotics, which suggested that X11 had the potential to be developed as a novel probiotic strain to ameliorate HUA.

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