Action Potentials in Epithelial Taste Receptor Cells Induced by Mucosal Calcium

Overview

Journal J Membr Biol

Date 1987 Jan 1

PMID 3585981

Citations 9

Authors

P Avenet

B Lindemann

Affiliations

Soon will be listed here.

Abstract

Chemosensory cells in the taste bud of the tongue of Necturus generate action potentials in response to electrical stimulation through a microelectrode, as recently described by Roper (Science, 220: 1311-1312, 1983). We report that the epithelial receptor cells also respond to 10 mM CaCl2, applied to the mucosal surface, with a depolarization which elicits action potentials when a threshold of -50 mV is reached. Since CaCl2 is one of the taste stimuli in amphibia, the firing of action potentials by chemoreceptor cells may be part of the signal chain in gustatory reception of Ca ions.

Citing Articles

ROS-GC subfamily membrane guanylate cyclase-linked transduction systems: taste, pineal gland and hippocampus.

Sharma R, Duda T Mol Cell Biochem. 2009; 334(1-2):199-206.

PMID: 19953306 DOI: 10.1007/s11010-009-0334-8.

Amino acid-activated channels in the catfish taste system.

Kumazawa T, Brand J, Teeter J Biophys J. 1998; 75(6):2757-66.

PMID: 9826598 PMC: 1299949. DOI: 10.1016/S0006-3495(98)77719-7.

Amiloride-blockable sodium currents in isolated taste receptor cells.

Avenet P, Lindemann B J Membr Biol. 1988; 105(3):245-55.

PMID: 2851656 DOI: 10.1007/BF01871001.

Perspectives of taste reception.

Avenet P, Lindemann B J Membr Biol. 1989; 112(1):1-8.

PMID: 2687472 DOI: 10.1007/BF01871158.

Distribution of ion channels on taste cells and its relationship to chemosensory transduction.

Roper S, McBride Jr D J Membr Biol. 1989; 109(1):29-39.

PMID: 2475632 DOI: 10.1007/BF01870788.

References

Akaike N, Noma A, Sato M . Electrical responses to frog taste cells to chemical stimuli. J Physiol. 1976; 254(1):87-107. PMC: 1309182. DOI: 10.1113/jphysiol.1976.sp011223. View

Nagahama S, Kurihara K . Effects of respiratory inhibitors and ionophore A23187 on frog gustatory nerve responses. Comp Biochem Physiol A Comp Physiol. 1984; 79(3):431-5. DOI: 10.1016/0300-9629(84)90540-1. View

Dreyer F, Peper K . Iontophoretic application of acetylcholine: advantages of high resistance micropipettes in connection with an electronic current pump. Pflugers Arch. 1974; 348(3):263-72. DOI: 10.1007/BF00587417. View

Ozawa S, Miyazaki S . Electrical excitability in the rat clonal pituitary cell and its relation to hormone secretion. Jpn J Physiol. 1979; 29(4):411-26. DOI: 10.2170/jjphysiol.29.411. View

Fenwick E, Marty A, Neher E . Sodium and calcium channels in bovine chromaffin cells. J Physiol. 1982; 331:599-635. PMC: 1197771. DOI: 10.1113/jphysiol.1982.sp014394. View

Kashiwayanagi M, Miyake M, Kurihara K . Voltage-dependent Ca2+ channel and Na+ channel in frog taste cells. Am J Physiol. 1983; 244(1):C82-8. DOI: 10.1152/ajpcell.1983.244.1.C82. View

Rorsman P, Trube G . Calcium and delayed potassium currents in mouse pancreatic beta-cells under voltage-clamp conditions. J Physiol. 1986; 374:531-50. PMC: 1182737. DOI: 10.1113/jphysiol.1986.sp016096. View

West C, BERNARD R . Intracellular characteristics and responses of taste bud and lingual cells of the mudpuppy. J Gen Physiol. 1978; 72(3):305-26. PMC: 2228539. DOI: 10.1085/jgp.72.3.305. View

Barry P, Diamond J . Junction potentials, electrode standard potentials, and other problems in interpreting electrical properties of membranes. J Membr Biol. 2013; 3(1):93-122. DOI: 10.1007/BF01868010. View

10.

Farbman A, Yonkers J . Fine structure of the taste bud in the mud puppy, Necturus maculosus. Am J Anat. 1971; 131(3):353-69. DOI: 10.1002/aja.1001310306. View

11.

Kumazawa T, Kashiwayanagi M, Kurihara K . Neuroblastoma cell as a model for a taste cell: mechanism of depolarization in response to various bitter substances. Brain Res. 1985; 333(1):27-33. DOI: 10.1016/0006-8993(85)90120-9. View

12.

Morimoto K, Sato M . Role of monoamines in afferent synaptic transmission in frog taste organ. Jpn J Physiol. 1982; 32(5):855-71. DOI: 10.2170/jjphysiol.32.855. View

13.

HIGGINS Jr J, Cesaro L, Gebler B, Fromter E . Electrical properties of amphibian urinary bladder epithelia. I. Inverse relationship between potential difference and resistance in tightly mounted preparations. Pflugers Arch. 1975; 358(1):41-56. DOI: 10.1007/BF00584568. View

14.

Sato T . Recent advances in the physiology of taste cells. Prog Neurobiol. 1980; 14(1):25-67. DOI: 10.1016/0301-0082(80)90003-9. View

15.

Ensor D . A new moving-coil microelectrode puller. J Neurosci Methods. 1979; 1(1):95-105. DOI: 10.1016/0165-0270(79)90008-6. View

16.

Soeda H, Sakudo F, Noda K . Relation between translingual potential changes induced by NaCl in the bullfrog tongue and taste nerve activity. Jpn J Physiol. 1985; 35(6):1101-5. DOI: 10.2170/jjphysiol.35.1101. View

17.

Roper S . Regenerative impulses in taste cells. Science. 1983; 220(4603):1311-2. DOI: 10.1126/science.6857254. View

18.

McDONALD T . The slow inward calcium current in the heart. Annu Rev Physiol. 1982; 44:425-34. DOI: 10.1146/annurev.ph.44.030182.002233. View