BRAF V600E Expression in Primary Melanoma and Its Association With Death: A Population-Based, Retrospective, Cross-Sectional Study

Overview

Journal Cutis

Specialty Dermatology

Date 2022 Jul 20

PMID 35856752

Authors

Jamison A Harvey

Julia S Lehman

Christine M Lohse

Alanna M Chamberlain

Svetomir N Markovic

Celine M Vachon

Jerry D Brewer

Affiliations

Soon will be listed here.

Abstract

Approximately 50% of melanomas contain BRAF mutations; the effects on survival are unclear. We aimed to determine whether mutant BRAF expression in melanoma differs according to age, sex, and melanoma-specific survival. A total of 638 patients who resided in Olmsted County, Minnesota, with a first lifetime diagnosis of melanoma between 1970 and 2009 were identified from the Rochester Epidemiology Project (REP). Available tissue was analyzed for a BRAF V600E mutation with immunohistochemistry.

References

Thomas N, Edmiston S, Alexander A, Millikan R, Groben P, Hao H . Number of nevi and early-life ambient UV exposure are associated with BRAF-mutant melanoma. Cancer Epidemiol Biomarkers Prev. 2007; 16(5):991-7. DOI: 10.1158/1055-9965.EPI-06-1038. View

Thomas N, Edmiston S, Alexander A, Groben P, Parrish E, Kricker A . Association Between NRAS and BRAF Mutational Status and Melanoma-Specific Survival Among Patients With Higher-Risk Primary Melanoma. JAMA Oncol. 2015; 1(3):359-68. PMC: 4486299. DOI: 10.1001/jamaoncol.2015.0493. View

Shinozaki M, Fujimoto A, Morton D, Hoon D . Incidence of BRAF oncogene mutation and clinical relevance for primary cutaneous melanomas. Clin Cancer Res. 2004; 10(5):1753-7. DOI: 10.1158/1078-0432.ccr-1169-3. View

Reed K, Brewer J, Lohse C, Bringe K, Pruitt C, Gibson L . Increasing incidence of melanoma among young adults: an epidemiological study in Olmsted County, Minnesota. Mayo Clin Proc. 2012; 87(4):328-34. PMC: 3538462. DOI: 10.1016/j.mayocp.2012.01.010. View

Whiteman D, Parsons P, Green A . p53 expression and risk factors for cutaneous melanoma: a case-control study. Int J Cancer. 1998; 77(6):843-8. DOI: 10.1002/(sici)1097-0215(19980911)77:6<843::aid-ijc8>3.0.co;2-u. View

Liu W, Kelly J, Trivett M, Murray W, Dowling J, Wolfe R . Distinct clinical and pathological features are associated with the BRAF(T1799A(V600E)) mutation in primary melanoma. J Invest Dermatol. 2006; 127(4):900-5. DOI: 10.1038/sj.jid.5700632. View

Olazagasti Lourido J, Ma J, Lohse C, Brewer J . Increasing Incidence of Melanoma in the Elderly: An Epidemiological Study in Olmsted County, Minnesota. Mayo Clin Proc. 2016; 91(11):1555-1562. PMC: 5118041. DOI: 10.1016/j.mayocp.2016.06.028. View

Larsen A, Dahl C, Dahmcke C, Lade-Keller J, Siersma V, Toft P . BRAF mutations in conjunctival melanoma: investigation of incidence, clinicopathological features, prognosis and paired premalignant lesions. Acta Ophthalmol. 2016; 94(5):463-70. DOI: 10.1111/aos.13007. View

Lowe G, Saavedra A, Reed K, Velazquez A, Dronca R, Markovic S . Increasing incidence of melanoma among middle-aged adults: an epidemiologic study in Olmsted County, Minnesota. Mayo Clin Proc. 2014; 89(1):52-9. PMC: 4389734. DOI: 10.1016/j.mayocp.2013.09.014. View

10.

Whiteman D, Watt P, Purdie D, Hughes M, Hayward N, Green A . Melanocytic nevi, solar keratoses, and divergent pathways to cutaneous melanoma. J Natl Cancer Inst. 2003; 95(11):806-12. DOI: 10.1093/jnci/95.11.806. View

11.

Kim S, Kim S, Hahn H, Lee Y, Choe Y, Ahn K . Metaanalysis of BRAF mutations and clinicopathologic characteristics in primary melanoma. J Am Acad Dermatol. 2015; 72(6):1036-46.e2. DOI: 10.1016/j.jaad.2015.02.1113. View

12.

Rocca W, Yawn B, St Sauver J, Grossardt B, Melton 3rd L . History of the Rochester Epidemiology Project: half a century of medical records linkage in a US population. Mayo Clin Proc. 2012; 87(12):1202-13. PMC: 3541925. DOI: 10.1016/j.mayocp.2012.08.012. View

13.

Mar V, Liu W, Devitt B, Wong S, Dobrovic A, McArthur G . The role of BRAF mutations in primary melanoma growth rate and survival. Br J Dermatol. 2015; 173(1):76-82. DOI: 10.1111/bjd.13756. View

14.

Olsen C, Zens M, Green A, Stukel T, Holman C, Mack T . Biologic markers of sun exposure and melanoma risk in women: pooled case-control analysis. Int J Cancer. 2010; 129(3):713-23. PMC: 3035752. DOI: 10.1002/ijc.25691. View

15.

Grimaldi A, Cassidy P, Leachmann S, Ascierto P . Novel approaches in melanoma prevention and therapy. Cancer Treat Res. 2013; 159:443-55. DOI: 10.1007/978-3-642-38007-5_25. View

16.

Heppt M, Siepmann T, Engel J, Schubert-Fritschle G, Eckel R, Mirlach L . Prognostic significance of BRAF and NRAS mutations in melanoma: a German study from routine care. BMC Cancer. 2017; 17(1):536. PMC: 5553744. DOI: 10.1186/s12885-017-3529-5. View

17.

Curtin J, Fridlyand J, Kageshita T, Patel H, Busam K, Kutzner H . Distinct sets of genetic alterations in melanoma. N Engl J Med. 2005; 353(20):2135-47. DOI: 10.1056/NEJMoa050092. View