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CD4 Regulatory and Naïve T Cells Specific for Factor VIII Stand Vis-à-vis to Balance the Immune Response in Healthy Individuals

Overview
Journal EJHaem
Specialty Hematology
Date 2022 Jul 18
PMID 35845215
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The self-reactive FVIII T cell repertoire in healthy individuals relies on a short set of epitopes and public clonotypes.

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CD4 regulatory and naïve T cells specific for factor VIII stand vis-à-vis to balance the immune response in healthy individuals.

Schmidt A, Orlowski A, Salzmann-Manrique E, Konigs C EJHaem. 2022; 2(4):805-808.

PMID: 35845215 PMC: 9175863. DOI: 10.1002/jha2.319.

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Klein L, Kyewski B, Allen P, Hogquist K . Positive and negative selection of the T cell repertoire: what thymocytes see (and don't see). Nat Rev Immunol. 2014; 14(6):377-91. PMC: 4757912. DOI: 10.1038/nri3667. View

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Schmidt A, Orlowski A, Salzmann-Manrique E, Konigs C . CD4 regulatory and naïve T cells specific for factor VIII stand vis-à-vis to balance the immune response in healthy individuals. EJHaem. 2022; 2(4):805-808. PMC: 9175863. DOI: 10.1002/jha2.319. View