A Reduction of Syndecan-4 in Macrophages Promotes Atherosclerosis by Aggravating the Proinflammatory Capacity of Macrophages

Overview

Journal J Transl Med

Publisher Biomed Central

Specialties Biomedical Engineering
General Medicine

Date 2022 Jul 16

PMID 35842658

Authors

Jiaxin Hu

Ying Zhang

Liaoping Hu

Haiting Chen

Han Wu

Jianzhou Chen

Jun Xie

Biao Xu

Zhonghai Wei

Affiliations

Soon will be listed here.

Abstract

Background: Cardiovascular diseases (CVDs) are a significant cause of mortality worldwide and are characterized by severe atherosclerosis (AS) in patients. However, the molecular mechanism of AS formation remains elusive. In the present study, we investigated the role of syndecan-4 (SDC4), a member of the syndecan family, in atherogenesis.

Methods And Results: The expression of SDC4 decreased in mouse severe AS models. Moreover, knockout of SDC4 accelerated high-cholesterol diets (HCD)-induced AS in ApoE mice. Mechanistically, the decrease of SDC4 increased macrophage proinflammatory capacity may be through the PKCα-ABCA1/ABCG1 signaling pathway.

Conclusion: These findings provide evidence that SDC4 reduction links macrophages and inflammation to AS and that SDC4 in macrophages provides a therapeutic target for preventing AS formation.

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