Developments in Deep Brain Stimulators for Successful Aging Towards Smart Devices-An Overview

Overview

Journal Front Aging

Specialty Geriatrics

Date 2022 Jul 13

PMID 35821845

Authors

Angelito A Silverio

Lean Angelo A Silverio

Affiliations

Soon will be listed here.

Abstract

This work provides an overview of the present state-of-the-art in the development of deep brain Deep Brain Stimulation (DBS) and how such devices alleviate motor and cognitive disorders for a successful aging. This work reviews chronic diseases that are addressable via DBS, reporting also the treatment efficacies. The underlying mechanism for DBS is also reported. A discussion on hardware developments focusing on DBS control paradigms is included specifically the open- and closed-loop "smart" control implementations. Furthermore, developments towards a "smart" DBS, while considering the design challenges, current state of the art, and constraints, are also presented. This work also showcased different methods, using ambient energy scavenging, that offer alternative solutions to prolong the battery life of the DBS device. These are geared towards a low maintenance, semi-autonomous, and less disruptive device to be used by the elderly patient suffering from motor and cognitive disorders.

References

Parastarfeizabadi M, Kouzani A . Advances in closed-loop deep brain stimulation devices. J Neuroeng Rehabil. 2017; 14(1):79. PMC: 5553781. DOI: 10.1186/s12984-017-0295-1. View

Kajikawa Y, Schroeder C . How local is the local field potential?. Neuron. 2011; 72(5):847-58. PMC: 3240862. DOI: 10.1016/j.neuron.2011.09.029. View

Smith G, Laxton A, Tang-Wai D, McAndrews M, Diaconescu A, Workman C . Increased cerebral metabolism after 1 year of deep brain stimulation in Alzheimer disease. Arch Neurol. 2012; 69(9):1141-8. DOI: 10.1001/archneurol.2012.590. View

Montgomery Jr E, Gale J . Mechanisms of action of deep brain stimulation(DBS) . Neurosci Biobehav Rev. 2007; 32(3):388-407. DOI: 10.1016/j.neubiorev.2007.06.003. View

Flajolet M, Wang Z, Futter M, Shen W, Nuangchamnong N, Bendor J . FGF acts as a co-transmitter through adenosine A(2A) receptor to regulate synaptic plasticity. Nat Neurosci. 2008; 11(12):1402-9. PMC: 2779562. DOI: 10.1038/nn.2216. View

Kupsch A, Benecke R, Muller J, Trottenberg T, Schneider G, Poewe W . Pallidal deep-brain stimulation in primary generalized or segmental dystonia. N Engl J Med. 2006; 355(19):1978-90. DOI: 10.1056/NEJMoa063618. View

Volkmann J, Herzog J, Kopper F, Deuschl G . Introduction to the programming of deep brain stimulators. Mov Disord. 2002; 17 Suppl 3:S181-7. DOI: 10.1002/mds.10162. View

Tran T, Vo T, Frei K, Truong D . Levodopa-induced dyskinesia: clinical features, incidence, and risk factors. J Neural Transm (Vienna). 2018; 125(8):1109-1117. DOI: 10.1007/s00702-018-1900-6. View

Khaleeq T, Hasegawa H, Samuel M, Ashkan K . Fixed-Life or Rechargeable Battery for Deep Brain Stimulation: Which Do Patients Prefer?. Neuromodulation. 2018; 22(4):489-492. DOI: 10.1111/ner.12810. View

10.

Deuschl G, Petersen I, Lorenz D, Christensen K . Tremor in the elderly: Essential and aging-related tremor. Mov Disord. 2015; 30(10):1327-34. PMC: 4779797. DOI: 10.1002/mds.26265. View

11.

Zangiabadi N, Ladino L, Sina F, Pablo Orozco-Hernandez J, Carter A, Tellez-Zenteno J . Deep Brain Stimulation and Drug-Resistant Epilepsy: A Review of the Literature. Front Neurol. 2019; 10:601. PMC: 6563690. DOI: 10.3389/fneur.2019.00601. View

12.

Baizabal-Carvallo J, Alonso-Juarez M . Low-frequency deep brain stimulation for movement disorders. Parkinsonism Relat Disord. 2016; 31:14-22. DOI: 10.1016/j.parkreldis.2016.07.018. View

13.

Little S, Brown P . What brain signals are suitable for feedback control of deep brain stimulation in Parkinson's disease?. Ann N Y Acad Sci. 2012; 1265:9-24. PMC: 3495297. DOI: 10.1111/j.1749-6632.2012.06650.x. View

14.

Bratsos S, Karponis D, Saleh S . Efficacy and Safety of Deep Brain Stimulation in the Treatment of Parkinson's Disease: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Cureus. 2019; 10(10):e3474. PMC: 6318091. DOI: 10.7759/cureus.3474. View

15.

Peto V, Jenkinson C, Fitzpatrick R . PDQ-39: a review of the development, validation and application of a Parkinson's disease quality of life questionnaire and its associated measures. J Neurol. 1998; 245 Suppl 1:S10-4. DOI: 10.1007/pl00007730. View

16.

Schupbach W, Chastan N, Welter M, Houeto J, Mesnage V, Bonnet A . Stimulation of the subthalamic nucleus in Parkinson's disease: a 5 year follow up. J Neurol Neurosurg Psychiatry. 2005; 76(12):1640-4. PMC: 1739461. DOI: 10.1136/jnnp.2005.063206. View

17.

Ostrem J, Starr P . Treatment of dystonia with deep brain stimulation. Neurotherapeutics. 2008; 5(2):320-30. PMC: 5084173. DOI: 10.1016/j.nurt.2008.01.002. View

18.

Okun M, Gallo B, Mandybur G, Jagid J, Foote K, Revilla F . Subthalamic deep brain stimulation with a constant-current device in Parkinson's disease: an open-label randomised controlled trial. Lancet Neurol. 2012; 11(2):140-9. DOI: 10.1016/S1474-4422(11)70308-8. View

19.

Wang Y, Luo H, Chen Y, Jiao Z, Sun Q, Dong L . A Closed-Loop Neuromodulation Chipset With 2-Level Classification Achieving 1.5-Vpp CM Interference Tolerance, 35-dB Stimulation Artifact Rejection in 0.5ms and 97.8%-Sensitivity Seizure Detection. IEEE Trans Biomed Circuits Syst. 2021; 15(4):802-819. DOI: 10.1109/TBCAS.2021.3102261. View

20.

Luo Y, Sun Y, Tian X, Zheng X, Wang X, Li W . Deep Brain Stimulation for Alzheimer's Disease: Stimulation Parameters and Potential Mechanisms of Action. Front Aging Neurosci. 2021; 13:619543. PMC: 7990787. DOI: 10.3389/fnagi.2021.619543. View