What Brain Signals Are Suitable for Feedback Control of Deep Brain Stimulation in Parkinson's Disease?

Overview

Journal Ann N Y Acad Sci

Specialty Science

Date 2012 Jul 27

PMID 22830645

Citations 116

Authors

Simon Little

Peter Brown

Affiliations

Soon will be listed here.

Abstract

Feedback control of deep brain stimulation (DBS) in Parkinson's disease has great potential to improve efficacy, reduce side effects, and decrease the cost of treatment. In this, the timing and intensity of stimulation are titrated according to biomarkers that capture current clinical state. Stimulation may be at standard high frequency or intelligently patterned to directly modify specific pathological rhythms. The search for and validation of appropriate feedback signals are therefore crucial. Signals recorded from the DBS electrode currently appear to be the most promising source of feedback. In particular, beta-frequency band oscillations in the local field potential recorded at the stimulation target may capture variation in bradykinesia and rigidity across patients, but this remains to be confirmed within patients. Biomarkers that reliably reflect other impairments, such as tremor, also need to be established. Finally, whether brain signals are causally important needs to be established before stimulation can be specifically patterned rather than delivered at empirically defined high frequency.

Citing Articles

Local Field Potential Biomarkers of Non-Motor Symptoms in Parkinson's Disease: Insights From the Subthalamic Nucleus in Deep Brain Stimulation.

Gobeil M, Guillemette A, Silhadi M, Charbonneau L, Bergeron D, Dominguez-Vargas A Eur J Neurosci. 2025; 61(5):e70046.

PMID: 40040306 PMC: 11880747. DOI: 10.1111/ejn.70046.

Electrophysiological approaches to informing therapeutic interventions with deep brain stimulation.

Asadi A, Wiesman A, Wiest C, Baillet S, Tan H, Muthuraman M NPJ Parkinsons Dis. 2025; 11(1):20.

PMID: 39833210 PMC: 11747345. DOI: 10.1038/s41531-024-00847-3.

Artificial Intelligence-Based Methodologies for Early Diagnostic Precision and Personalized Therapeutic Strategies in Neuro-Ophthalmic and Neurodegenerative Pathologies.

Kumar R, Waisberg E, Ong J, Paladugu P, Amiri D, Saintyl J Brain Sci. 2025; 14(12.

PMID: 39766465 PMC: 11674895. DOI: 10.3390/brainsci14121266.

Interaction of motor behaviour, cortical oscillations and deep brain stimulation in Parkinson's disease.

Mirpour K, Pouratian N Brain. 2024; 148(3):886-895.

PMID: 39300838 PMC: 11884658. DOI: 10.1093/brain/awae300.

Sensing data and methodology from the Adaptive DBS Algorithm for Personalized Therapy in Parkinson's Disease (ADAPT-PD) clinical trial.

Stanslaski S, Summers R, Tonder L, Tan Y, Case M, Raike R NPJ Parkinsons Dis. 2024; 10(1):174.

PMID: 39289373 PMC: 11408616. DOI: 10.1038/s41531-024-00772-5.

References

Androulidakis A, Brucke C, Kempf F, Kupsch A, Aziz T, Ashkan K . Amplitude modulation of oscillatory activity in the subthalamic nucleus during movement. Eur J Neurosci. 2008; 27(5):1277-84. DOI: 10.1111/j.1460-9568.2008.06085.x. View

Ozkurt T, Butz M, Homburger M, Elben S, Vesper J, Wojtecki L . High frequency oscillations in the subthalamic nucleus: a neurophysiological marker of the motor state in Parkinson's disease. Exp Neurol. 2011; 229(2):324-31. DOI: 10.1016/j.expneurol.2011.02.015. View

Kuhn A, Kupsch A, Schneider G, Brown P . Reduction in subthalamic 8-35 Hz oscillatory activity correlates with clinical improvement in Parkinson's disease. Eur J Neurosci. 2006; 23(7):1956-60. DOI: 10.1111/j.1460-9568.2006.04717.x. View

Priori A, Foffani G, Pesenti A, Tamma F, Bianchi A, Pellegrini M . Rhythm-specific pharmacological modulation of subthalamic activity in Parkinson's disease. Exp Neurol. 2004; 189(2):369-79. DOI: 10.1016/j.expneurol.2004.06.001. View

Schwartz A, Cui X, Weber D, Moran D . Brain-controlled interfaces: movement restoration with neural prosthetics. Neuron. 2006; 52(1):205-20. DOI: 10.1016/j.neuron.2006.09.019. View

Zaidel A, Spivak A, Grieb B, Bergman H, Israel Z . Subthalamic span of beta oscillations predicts deep brain stimulation efficacy for patients with Parkinson's disease. Brain. 2010; 133(Pt 7):2007-21. DOI: 10.1093/brain/awq144. View

Fogelson N, Kuhn A, Silberstein P, Limousin P, Hariz M, Trottenberg T . Frequency dependent effects of subthalamic nucleus stimulation in Parkinson's disease. Neurosci Lett. 2005; 382(1-2):5-9. DOI: 10.1016/j.neulet.2005.02.050. View

Muller V, Lutzenberger W, Pulvermuller F, Mohr B, Birbaumer N . Investigation of brain dynamics in Parkinson's disease by methods derived from nonlinear dynamics. Exp Brain Res. 2001; 137(1):103-10. DOI: 10.1007/s002210000638. View

Morrell M . Responsive cortical stimulation for the treatment of medically intractable partial epilepsy. Neurology. 2011; 77(13):1295-304. DOI: 10.1212/WNL.0b013e3182302056. View

10.

Kim J, Lee J, Kwon Y, Kim C, Eom G, Koh S . Quantification of bradykinesia during clinical finger taps using a gyrosensor in patients with Parkinson's disease. Med Biol Eng Comput. 2010; 49(3):365-71. DOI: 10.1007/s11517-010-0697-8. View

11.

Stam C . Nonlinear dynamical analysis of EEG and MEG: review of an emerging field. Clin Neurophysiol. 2005; 116(10):2266-301. DOI: 10.1016/j.clinph.2005.06.011. View

12.

Bassett D, Gazzaniga M . Understanding complexity in the human brain. Trends Cogn Sci. 2011; 15(5):200-9. PMC: 3170818. DOI: 10.1016/j.tics.2011.03.006. View

13.

Ray N, Jenkinson N, Wang S, Holland P, Brittain J, Joint C . Local field potential beta activity in the subthalamic nucleus of patients with Parkinson's disease is associated with improvements in bradykinesia after dopamine and deep brain stimulation. Exp Neurol. 2008; 213(1):108-13. DOI: 10.1016/j.expneurol.2008.05.008. View

14.

Stefani A, Lozano A, Peppe A, Stanzione P, Galati S, Tropepi D . Bilateral deep brain stimulation of the pedunculopontine and subthalamic nuclei in severe Parkinson's disease. Brain. 2007; 130(Pt 6):1596-607. DOI: 10.1093/brain/awl346. View

15.

Fries P . A mechanism for cognitive dynamics: neuronal communication through neuronal coherence. Trends Cogn Sci. 2005; 9(10):474-80. DOI: 10.1016/j.tics.2005.08.011. View

16.

ALLEN D, Playfer J, Aly N, Duffey P, Heald A, Smith S . On the use of low-cost computer peripherals for the assessment of motor dysfunction in Parkinson's disease--quantification of bradykinesia using target tracking tasks. IEEE Trans Neural Syst Rehabil Eng. 2007; 15(2):286-94. DOI: 10.1109/TNSRE.2007.897020. View

17.

Urrestarazu E, Iriarte J, Alegre M, Clavero P, Rodriguez-Oroz M, Guridi J . Beta activity in the subthalamic nucleus during sleep in patients with Parkinson's disease. Mov Disord. 2008; 24(2):254-60. DOI: 10.1002/mds.22351. View

18.

Friston K . The labile brain. I. Neuronal transients and nonlinear coupling. Philos Trans R Soc Lond B Biol Sci. 2000; 355(1394):215-36. PMC: 1692735. DOI: 10.1098/rstb.2000.0560. View

19.

Schiff S . Towards model-based control of Parkinson's disease. Philos Trans A Math Phys Eng Sci. 2010; 368(1918):2269-308. PMC: 2944387. DOI: 10.1098/rsta.2010.0050. View

20.

Rossi L, Foffani G, Marceglia S, Bracchi F, Barbieri S, Priori A . An electronic device for artefact suppression in human local field potential recordings during deep brain stimulation. J Neural Eng. 2007; 4(2):96-106. DOI: 10.1088/1741-2560/4/2/010. View