Local BMP Signaling: A Sensor for Synaptic Activity That Balances Synapse Growth and Function

Overview

Journal Curr Top Dev Biol

Publisher Elsevier

Specialties Biology
Reproductive Medicine

Date 2022 Jul 11

PMID 35817503

Authors

Rosario Vicidomini

Mihaela Serpe

Affiliations

Soon will be listed here.

Abstract

Synapse development is coordinated by intercellular communication between the pre- and postsynaptic compartments, and by neuronal activity itself. In flies as in vertebrates, neuronal activity induces input-specific changes in the synaptic strength so that the entire circuit maintains stable function in the face of many challenges, including changes in synapse number and strength. But how do neurons sense synapse activity? In several studies carried out using the Drosophila neuromuscular junction (NMJ), we demonstrated that local BMP signaling provides an exquisite sensor for synapse activity. Here we review the main features of this exquisite sensor and discuss its functioning beyond monitoring the synapse activity but rather as a key controller that operates in coordination with other BMP signaling pathways to balance synapse growth, maturation and function.

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