Combination of C. A. Mey and Febuxostat Boasted Cardioprotective Effects Against Doxorubicin-Induced Acute Cardiotoxicity in Rats

Overview

Journal Front Pharmacol

Date 2022 Jul 11

PMID 35814241

Authors

Hayder M Al-Kuraishy

Hany A Al-Hussaniy

Ali I Al-Gareeb

Walaa A Negm

Aya H El-Kadem

Gaber El-Saber Batiha

Nermeen N Welson

Gomaa Mostafa-Hedeab

Ahmed H Qasem

Carlos Adam Conte-Junior

Affiliations

Soon will be listed here.

Abstract

Doxorubicin (DOX) is an anticancer agent for treating solid and soft tissue malignancies. However, the clinical use of DOX is restricted by cumulative, dose-dependent cardiotoxicity. Therefore, the present study aimed to assess the cardioprotective effects of C. A. Mey, febuxostat, and their combination against DOX-induced cardiotoxicity. Thirty-five Sprague Dawley male rats were used in this study. The animals were randomly divided into five groups, with seven rats per group. The control group received normal saline, the induced group received DOX only, and the treated group received , febuxostat, and their combination before DOX treatment. Biomarkers of acute cardiac toxicity were assessed in each group. Results showed that treatment with the combination of febuxostat and before DOX led to a significant improvement in the biomarkers of acute DOX-induced cardiotoxicity. In conclusion, the combination of and febuxostat produced more significant cardioprotective effects against DOX-induced cardiotoxicity when compared to either or febuxostat when used alone. The potential mechanism of this combination was mainly mediated by the anti-inflammatory and antioxidant effects of and febuxostat.

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References

Hamza A, Heeba G, Hamza S, Abdalla A, Amin A . Standardized extract of ginger ameliorates liver cancer by reducing proliferation and inducing apoptosis through inhibition oxidative stress/ inflammation pathway. Biomed Pharmacother. 2020; 134:111102. DOI: 10.1016/j.biopha.2020.111102. View

Al-Shamsi M, Amin A, Adeghate E . Effect of vitamin C on liver and kidney functions in normal and diabetic rats. Ann N Y Acad Sci. 2006; 1084:371-90. DOI: 10.1196/annals.1372.031. View

Xie Y, Mu C, Kazybay B, Sun Q, Kutzhanova A, Nazarbek G . Network pharmacology and experimental investigation of extract targeted kinase with herbzyme activity for potent drug delivery. Drug Deliv. 2021; 28(1):2187-2197. PMC: 8526013. DOI: 10.1080/10717544.2021.1977422. View

Mohan N, Jiang J, Dokmanovic M, Wu W . Trastuzumab-mediated cardiotoxicity: current understanding, challenges, and frontiers. Antib Ther. 2018; 1(1):13-17. PMC: 6131716. DOI: 10.1093/abt/tby003. View

Li L, Li J, Wang Q, Zhao X, Yang D, Niu L . Shenmai Injection Protects Against Doxorubicin-Induced Cardiotoxicity Maintaining Mitochondrial Homeostasis. Front Pharmacol. 2020; 11:815. PMC: 7289952. DOI: 10.3389/fphar.2020.00815. View

Wang G, Lei C, Tian Y, Wang Y, Zhang L, Zhang R . Rb1, the Primary Active Ingredient in C.A. Meyer, Exerts Antidepressant-Like Effects the BDNF-Trkb-CREB Pathway. Front Pharmacol. 2019; 10:1034. PMC: 6753202. DOI: 10.3389/fphar.2019.01034. View

Abdel-Aziz A, Gamal El-Tahawy N, Salah Abdel Haleem M, Mohammed M, Ali A, Ibrahim Y . Amelioration of testosterone-induced benign prostatic hyperplasia using febuxostat in rats: The role of VEGF/TGFβ and iNOS/COX-2. Eur J Pharmacol. 2020; 889:173631. DOI: 10.1016/j.ejphar.2020.173631. View

El-Kharrag R, Amin A, Hisaindee S, Greish Y, Karam S . Development of a therapeutic model of precancerous liver using crocin-coated magnetite nanoparticles. Int J Oncol. 2016; 50(1):212-222. DOI: 10.3892/ijo.2016.3769. View

Abushouk A, Salem A, Saad A, Afifi A, Afify A, Afify H . Mesenchymal Stem Cell Therapy for Doxorubicin-Induced Cardiomyopathy: Potential Mechanisms, Governing Factors, and Implications of the Heart Stem Cell Debate. Front Pharmacol. 2019; 10:635. PMC: 6586740. DOI: 10.3389/fphar.2019.00635. View

10.

Lenihan D . Cardiac biomarkers, cardiotoxicity, and active collaboration: is this the final frontier or the wave we should catch?. J Am Coll Cardiol. 2013; 63(8):817-8. DOI: 10.1016/j.jacc.2013.10.060. View

11.

Podyacheva E, Kushnareva E, Karpov A, Toropova Y . Analysis of Models of Doxorubicin-Induced Cardiomyopathy in Rats and Mice. A Modern View From the Perspective of the Pathophysiologist and the Clinician. Front Pharmacol. 2021; 12:670479. PMC: 8209419. DOI: 10.3389/fphar.2021.670479. View

12.

Shim J, Chun B, van Hasselt J, Birtwistle M, Saucerman J, Sobie E . Mechanistic Systems Modeling to Improve Understanding and Prediction of Cardiotoxicity Caused by Targeted Cancer Therapeutics. Front Physiol. 2017; 8:651. PMC: 5599787. DOI: 10.3389/fphys.2017.00651. View

13.

Zhang Q, Wang F, Jia K, Kong L . Natural Product Interventions for Chemotherapy and Radiotherapy-Induced Side Effects. Front Pharmacol. 2018; 9:1253. PMC: 6232953. DOI: 10.3389/fphar.2018.01253. View

14.

Murabito A, Hirsch E, Ghigo A . Mechanisms of Anthracycline-Induced Cardiotoxicity: Is Mitochondrial Dysfunction the Answer?. Front Cardiovasc Med. 2020; 7:35. PMC: 7080657. DOI: 10.3389/fcvm.2020.00035. View

15.

Sheppard R, Berger J, Sebag I . Cardiotoxicity of cancer therapeutics: current issues in screening, prevention, and therapy. Front Pharmacol. 2013; 4:19. PMC: 3594741. DOI: 10.3389/fphar.2013.00019. View

16.

Chen Y, Wang L, Liu T, Qiu Z, Qiu Y, Liu D . Inhibitory effects of glycoproteins in models of doxorubicin-induced cardiac toxicity and . Food Funct. 2021; 12(21):10862-10874. DOI: 10.1039/d1fo01307f. View

17.

Xu H, Yu W, Sun S, Li C, Zhang Y, Ren J . Luteolin Attenuates Doxorubicin-Induced Cardiotoxicity Through Promoting Mitochondrial Autophagy. Front Physiol. 2020; 11:113. PMC: 7033739. DOI: 10.3389/fphys.2020.00113. View

18.

Cardinale D, Iacopo F, Cipolla C . Cardiotoxicity of Anthracyclines. Front Cardiovasc Med. 2020; 7:26. PMC: 7093379. DOI: 10.3389/fcvm.2020.00026. View

19.

Al-Shamsi M, Amin A, Adeghate E . Vitamin E ameliorates some biochemical parameters in normal and diabetic rats. Ann N Y Acad Sci. 2006; 1084:411-31. DOI: 10.1196/annals.1372.033. View

20.

El-Mahdy N, Saleh D, Amer M, Abu-Risha S . Role of allopurinol and febuxostat in the amelioration of dextran-induced colitis in rats. Eur J Pharm Sci. 2019; 141:105116. DOI: 10.1016/j.ejps.2019.105116. View