Customized Design 3D Printed PLGA/Calcium Sulfate Scaffold Enhances Mechanical and Biological Properties for Bone Regeneration

Overview

Journal Front Bioeng Biotechnol

Date 2022 Jul 11

PMID 35814012

Authors

Tao Liu

Zhan Li

Li Zhao

Zehua Chen

Zefeng Lin

Binglin Li

Zhibin Feng

Panshi Jin

Jinwei Zhang

Zugui Wu

Huai Wu

Xuemeng Xu

Xiangling Ye

Ying Zhang

Affiliations

Soon will be listed here.

Abstract

Polylactic glycolic acid copolymer (PLGA) has been widely used in tissue engineering due to its good biocompatibility and degradation properties. However, the mismatched mechanical and unsatisfactory biological properties of PLGA limit further application in bone tissue engineering. Calcium sulfate (CaSO) is one of the most promising bone repair materials due to its non-immunogenicity, well biocompatibility, and excellent bone conductivity. In this study, aiming at the shortcomings of activity-lack and low mechanical of PLGA in bone tissue engineering, customized-designed 3D porous PLGA/CaSO scaffolds were prepared by 3D printing. We first studied the physical properties of PLGA/CaSO scaffolds and the results showed that CaSO improved the mechanical properties of PLGA scaffolds. experiments showed that PLGA/CaSO scaffold exhibited good biocompatibility. Moreover, the addition of CaSO could significantly improve the migration and osteogenic differentiation of MC3T3-E1 cells in the PLGA/CaSO scaffolds, and the PLGA/CaSO scaffolds made with 20 wt.% CaSO exhibited the best osteogenesis properties. Therefore, calcium sulfate was added to PLGA could lead to customized 3D printed scaffolds for enhanced mechanical properties and biological properties. The customized 3D-printed PLGA/CaSO scaffold shows great potential for precisely repairing irregular load-bearing bone defects.

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