Poly(lactic--glycolic Acid)-based Composite Bone-substitute Materials

Overview

Journal Bioact Mater

Specialty Biomedical Engineering

Date 2020 Sep 21

PMID 32954053

Citations 125

Authors

Duoyi Zhao

Tongtong Zhu

Jie Li

Liguo Cui

Zhiyu Zhang

Xiuli Zhuang

Jianxun Ding

Affiliations

Soon will be listed here.

Abstract

Research and development of the ideal artificial bone-substitute materials to replace autologous and allogeneic bones for repairing bone defects is still a challenge in clinical orthopedics. Recently, poly(lactic--glycolic acid) (PLGA)-based artificial bone-substitute materials are attracting increasing attention as the benefit of their suitable biocompatibility, degradability, mechanical properties, and capabilities to promote bone regeneration. In this article, we comprehensively review the artificial bone-substitute materials made from PLGA or the composites of PLGA and other organic and inorganic substances, elaborate on their applications for bone regeneration with or without bioactive factors, and prospect the challenges and opportunities in clinical bone regeneration.

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