Therapeutic Application of PPE2 Protein Of Mycobacterium Tuberculosis in Inhibiting Tissue Inflammation

Overview

Journal EMBO Mol Med

Specialty Molecular Biology

Date 2022 Jul 11

PMID 35811493

Authors

Ravi Pal

Madhu Babu Battu

Sangita Mukhopadhyay

Affiliations

Soon will be listed here.

Abstract

There is an increasing need to develop biological anti-inflammatory agents that are more targeted, effective, and with lesser side effects as compared to conventional chemical drugs. In the present study, we found that Mycobacterium tuberculosis protein PPE2 and a synthetic derivative peptide can suppress the mast cell population and inhibit several vasoactive and fibrogenic mediators and pro-inflammatory cytokines induced by mast cells in formalin-induced tissue injury. PPE2 was found to inhibit transcription from the promoter of stem cell factor, important for mast cell maintenance and migration. Thus, PPE2/peptide can be used as a potent nonsteroidal therapeutic agent for the treatment of inflammation and tissue injury.

Citing Articles

Therapeutic application of PPE2 protein of Mycobacterium tuberculosis in inhibiting tissue inflammation.

Pal R, Battu M, Mukhopadhyay S EMBO Mol Med. 2022; 14(9):e14891.

PMID: 35811493 PMC: 9449591. DOI: 10.15252/emmm.202114891.

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