Aging of Vascular System Is a Complex Process: The Cornerstone Mechanisms

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2022 Jul 9

PMID 35805936

Authors

Anastasia V Poznyak

Nikolay K Sadykhov

Andrey G Kartuesov

Evgeny E Borisov

Vasily N Sukhorukov

Alexander N Orekhov

Affiliations

Soon will be listed here.

Abstract

Aging is one of the most intriguing processes of human ontogenesis. It is associated with the development of a wide variety of diseases affecting all organs and their systems. The victory over aging is the most desired goal of scientists; however, it is hardly achievable in the foreseeable future due to the complexity and ambiguity of the process itself. All body systems age, lose their performance, and structural disorders accumulate. The cardiovascular system is no exception. And it is cardiovascular diseases that occupy a leading position as a cause of death, especially among the elderly. The aging of the cardiovascular system is well described from a mechanical point of view. Moreover, it is known that at the cellular level, a huge number of mechanisms are involved in this process, from mitochondrial dysfunction to inflammation. It is on these mechanisms, as well as the potential for taking control of the aging of the cardiovascular system, that we focused on in this review.

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References

Kietzmann T, Petry A, Shvetsova A, Gerhold J, Gorlach A . The epigenetic landscape related to reactive oxygen species formation in the cardiovascular system. Br J Pharmacol. 2017; 174(12):1533-1554. PMC: 5446579. DOI: 10.1111/bph.13792. View

Akhigbe R, Ajayi A . The impact of reactive oxygen species in the development of cardiometabolic disorders: a review. Lipids Health Dis. 2021; 20(1):23. PMC: 7916299. DOI: 10.1186/s12944-021-01435-7. View

Fu Q, Xiang Y . Trafficking of β-Adrenergic Receptors: Implications in Intracellular Receptor Signaling. Prog Mol Biol Transl Sci. 2015; 132:151-88. PMC: 7328190. DOI: 10.1016/bs.pmbts.2015.03.008. View

Giam M, Rancati G . Aneuploidy and chromosomal instability in cancer: a jackpot to chaos. Cell Div. 2015; 10:3. PMC: 4443636. DOI: 10.1186/s13008-015-0009-7. View

Kang T . Nuclear Factor-Erythroid 2-Related Factor 2 (Nrf2) and Mitochondrial Dynamics/Mitophagy in Neurological Diseases. Antioxidants (Basel). 2020; 9(7). PMC: 7402121. DOI: 10.3390/antiox9070617. View

Yegorov Y, Poznyak A, Nikiforov N, Starodubova A, Orekhov A . Role of Telomeres Shortening in Atherogenesis: An Overview. Cells. 2021; 10(2). PMC: 7918954. DOI: 10.3390/cells10020395. View

Jafri M, Ansari S, Alqahtani M, Shay J . Roles of telomeres and telomerase in cancer, and advances in telomerase-targeted therapies. Genome Med. 2016; 8(1):69. PMC: 4915101. DOI: 10.1186/s13073-016-0324-x. View

DeVallance E, Li Y, Jurczak M, Cifuentes-Pagano E, Pagano P . The Role of NADPH Oxidases in the Etiology of Obesity and Metabolic Syndrome: Contribution of Individual Isoforms and Cell Biology. Antioxid Redox Signal. 2019; 31(10):687-709. PMC: 6909742. DOI: 10.1089/ars.2018.7674. View

Liguori I, Russo G, Curcio F, Bulli G, Aran L, Della-Morte D . Oxidative stress, aging, and diseases. Clin Interv Aging. 2018; 13:757-772. PMC: 5927356. DOI: 10.2147/CIA.S158513. View

10.

Cassidy-Stone A, Chipuk J, Ingerman E, Song C, Yoo C, Kuwana T . Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization. Dev Cell. 2008; 14(2):193-204. PMC: 2267902. DOI: 10.1016/j.devcel.2007.11.019. View

11.

Aung L, Jumbo J, Wang Y, Li P . Therapeutic potential and recent advances on targeting mitochondrial dynamics in cardiac hypertrophy: A concise review. Mol Ther Nucleic Acids. 2021; 25:416-443. PMC: 8405900. DOI: 10.1016/j.omtn.2021.06.006. View

12.

Sharma A, Tate M, Mathew G, Vince J, Ritchie R, de Haan J . Oxidative Stress and NLRP3-Inflammasome Activity as Significant Drivers of Diabetic Cardiovascular Complications: Therapeutic Implications. Front Physiol. 2018; 9:114. PMC: 5826188. DOI: 10.3389/fphys.2018.00114. View

13.

Kozakova M, Palombo C . Vascular Ageing and Aerobic Exercise. Int J Environ Res Public Health. 2021; 18(20). PMC: 8535583. DOI: 10.3390/ijerph182010666. View

14.

Xin Y, Li J, Wu W, Liu X . Mitofusin-2: A New Mediator of Pathological Cell Proliferation. Front Cell Dev Biol. 2021; 9:647631. PMC: 8049505. DOI: 10.3389/fcell.2021.647631. View

15.

Meyts I, Aksentijevich I . Deficiency of Adenosine Deaminase 2 (DADA2): Updates on the Phenotype, Genetics, Pathogenesis, and Treatment. J Clin Immunol. 2018; 38(5):569-578. PMC: 6061100. DOI: 10.1007/s10875-018-0525-8. View

16.

Bloom C, North B . Physiological relevance of post-translational regulation of the spindle assembly checkpoint protein BubR1. Cell Biosci. 2021; 11(1):76. PMC: 8066494. DOI: 10.1186/s13578-021-00589-2. View

17.

Maas A, Appelman Y . Gender differences in coronary heart disease. Neth Heart J. 2011; 18(12):598-602. PMC: 3018605. DOI: 10.1007/s12471-010-0841-y. View

18.

Forte M, Schirone L, Ameri P, Basso C, Catalucci D, Modica J . The role of mitochondrial dynamics in cardiovascular diseases. Br J Pharmacol. 2020; 178(10):2060-2076. DOI: 10.1111/bph.15068. View

19.

Lee D, Kim J . PDI-mediated S-nitrosylation of DRP1 facilitates DRP1-S616 phosphorylation and mitochondrial fission in CA1 neurons. Cell Death Dis. 2018; 9(9):869. PMC: 6115394. DOI: 10.1038/s41419-018-0910-5. View

20.

Lee M, Sattar N, McMurray J, Packard C . Statins in the Prevention and Treatment of Heart Failure: a Review of the Evidence. Curr Atheroscler Rep. 2019; 21(10):41. PMC: 6660504. DOI: 10.1007/s11883-019-0800-z. View