Bibliometric Analysis of Global Research on Cancer Photodynamic Therapy: Focus on Nano-Related Research

Overview

Journal Front Pharmacol

Date 2022 Jul 5

PMID 35784740

Authors

Kunming Cheng

Qiang Guo

Zefeng Shen

Weiguang Yang

Yulin Wang

Zaijie Sun

Haiyang Wu

Affiliations

Soon will be listed here.

Abstract

A growing body of research has illuminated that photodynamic therapy (PDT) serves as an important therapeutic strategy in oncology and has become a hot topic in recent years. Although numerous papers related to cancer PDT (CPDT) have been published, no bibliometric studies have been conducted to summarize the research landscape, and highlight the research trends and hotspots in this field. This study collected 5,804 records on CPDT published between 2000 and 2021 from Web of Science Core Collection. Bibliometric analysis and visualization were conducted using VOSviewer, CiteSpace, and one online platform. The annual publication and citation results revealed significant increasing trends over the past 22 years. China and the United States, contributing 56.24% of the total publications, were the main driving force in this field. Chinese Academy of Sciences was the most prolific institution. and were the most productive and most co-cited journals, respectively. All keywords were categorized into four clusters including studies on nanomaterial technology, clinical applications, mechanism, and photosensitizers. "nanotech-based PDT" and "enhanced PDT" were current research hotspots. In addition to several nano-related topics such as "nanosphere," "nanoparticle," "nanomaterial," "nanoplatform," "nanomedicine" and "gold nanoparticle," the following topics including "photothermal therapy," "metal organic framework," "checkpoint blockade," "tumor microenvironment," "prodrug" also deserve further attention in the near future.

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References

Zheng D, Li B, Li C, Fan J, Lei Q, Li C . Carbon-Dot-Decorated Carbon Nitride Nanoparticles for Enhanced Photodynamic Therapy against Hypoxic Tumor via Water Splitting. ACS Nano. 2016; 10(9):8715-22. DOI: 10.1021/acsnano.6b04156. View

Yeung A, Georgieva M, Atanasov A, Tzvetkov N . Monoamine Oxidases (MAOs) as Privileged Molecular Targets in Neuroscience: Research Literature Analysis. Front Mol Neurosci. 2019; 12:143. PMC: 6549493. DOI: 10.3389/fnmol.2019.00143. View

Kwiatkowski S, Knap B, Przystupski D, Saczko J, Kedzierska E, Knap-Czop K . Photodynamic therapy - mechanisms, photosensitizers and combinations. Biomed Pharmacother. 2018; 106:1098-1107. DOI: 10.1016/j.biopha.2018.07.049. View

Monro S, Colon K, Yin H, Roque 3rd J, Konda P, Gujar S . Transition Metal Complexes and Photodynamic Therapy from a Tumor-Centered Approach: Challenges, Opportunities, and Highlights from the Development of TLD1433. Chem Rev. 2018; 119(2):797-828. PMC: 6453754. DOI: 10.1021/acs.chemrev.8b00211. View

Gao D, Gao Y, Shen J, Wang Q . Modified nanoscale metal organic framework-based nanoplatforms in photodynamic therapy and further applications. Photodiagnosis Photodyn Ther. 2020; 32:102026. DOI: 10.1016/j.pdpdt.2020.102026. View

Sahu A, Min K, Jeon J, Yang H, Tae G . Catalytic nanographene oxide with hemin for enhanced photodynamic therapy. J Control Release. 2020; 326:442-454. DOI: 10.1016/j.jconrel.2020.07.023. View

Roy I, Ohulchanskyy T, Pudavar H, Bergey E, Oseroff A, Morgan J . Ceramic-based nanoparticles entrapping water-insoluble photosensitizing anticancer drugs: a novel drug-carrier system for photodynamic therapy. J Am Chem Soc. 2003; 125(26):7860-5. DOI: 10.1021/ja0343095. View

Ou Z, Qiu L, Rong H, Li B, Ren S, Kuang S . Bibliometric Analysis of Chimeric Antigen Receptor-Based Immunotherapy in Cancers From 2001 to 2021. Front Immunol. 2022; 13:822004. PMC: 9005877. DOI: 10.3389/fimmu.2022.822004. View

Hu H, Yan X, Wang H, Tanaka J, Wang M, You W . Perfluorocarbon-based O nanocarrier for efficient photodynamic therapy. J Mater Chem B. 2020; 7(7):1116-1123. DOI: 10.1039/c8tb01844h. View

10.

Synnestvedt M, Chen C, Holmes J . CiteSpace II: visualization and knowledge discovery in bibliographic databases. AMIA Annu Symp Proc. 2006; :724-8. PMC: 1560567. View

11.

Biswas R, Mondal A, Ahn J . Deregulation of EGFR/PI3K and activation of PTEN by photodynamic therapy combined with carboplatin in human anaplastic thyroid cancer cells and xenograft tumors in nude mice. J Photochem Photobiol B. 2015; 148:118-127. DOI: 10.1016/j.jphotobiol.2015.03.024. View

12.

Dhilip Kumar S, Abrahamse H . Biocompatible Nanocarriers for Enhanced Cancer Photodynamic Therapy Applications. Pharmaceutics. 2021; 13(11). PMC: 8624654. DOI: 10.3390/pharmaceutics13111933. View

13.

Osuchowski M, Bartusik-Aebisher D, Osuchowski F, Aebisher D . Photodynamic therapy for prostate cancer - A narrative review. Photodiagnosis Photodyn Ther. 2020; 33:102158. DOI: 10.1016/j.pdpdt.2020.102158. View

14.

Yano T, Minamide T, Takashima K, Nakajo K, Kadota T, Yoda Y . Clinical Practice of Photodynamic Therapy Using Talaporfin Sodium for Esophageal Cancer. J Clin Med. 2021; 10(13). PMC: 8268336. DOI: 10.3390/jcm10132785. View

15.

Wu H, Zhou Y, Xu L, Tong L, Wang Y, Liu B . Mapping Knowledge Structure and Research Frontiers of Ultrasound-Induced Blood-Brain Barrier Opening: A Scientometric Study. Front Neurosci. 2021; 15:706105. PMC: 8316975. DOI: 10.3389/fnins.2021.706105. View

16.

Ahn S, Hwang J . Global Trends in Immunotherapy Research on Breast Cancer over the Past 10 Years. J Oncol. 2020; 2020:4708394. PMC: 7661143. DOI: 10.1155/2020/4708394. View

17.

Dolmans D, Fukumura D, Jain R . Photodynamic therapy for cancer. Nat Rev Cancer. 2003; 3(5):380-7. DOI: 10.1038/nrc1071. View

18.

Shi Y, Wei W, Li L, Wei Q, Jiang F, Xia G . The global status of research in breast cancer liver metastasis: a bibliometric and visualized analysis. Bioengineered. 2021; 12(2):12246-12262. PMC: 8810156. DOI: 10.1080/21655979.2021.2006552. View

19.

Gu X, Xie M, Jia R, Ge S . Publication Trends of Research on Retinoblastoma During 2001-2021: A 20-Year Bibliometric Analysis. Front Med (Lausanne). 2021; 8:675703. PMC: 8175655. DOI: 10.3389/fmed.2021.675703. View

20.

Meulemans J, Delaere P, Vander Poorten V . Photodynamic therapy in head and neck cancer: indications, outcomes, and future prospects. Curr Opin Otolaryngol Head Neck Surg. 2019; 27(2):136-141. DOI: 10.1097/MOO.0000000000000521. View