Multi-Omic Analyses Reveal Bifidogenic Effect and Metabolomic Shifts in Healthy Human Cohort Supplemented With a Prebiotic Dietary Fiber Blend

Overview

Journal Front Nutr

Specialty Nutritional Sciences

Date 2022 Jul 5

PMID 35782954

Authors

Jea Woo Kang

Xinyu Tang

Charles J Walton

Mark J Brown

Rachel A Brewer

Rolando L Maddela

Jack Jingyuan Zheng

Joanne K Agus

Angela M Zivkovic

Affiliations

Soon will be listed here.

Abstract

Clinical Trial Registration: www.clinicaltrials.gov/, identifier: NCT03785860.

Citing Articles

Efficacy and compatibility mechanism of bear bile powder in Shexiang Tongxin dropping pills for acute myocardial infarction treatment.

Luo Y, Zhang F, Zhu L, Ye J, Pan H, Lu X Chin Med. 2025; 20(1):14.

PMID: 39863867 PMC: 11763157. DOI: 10.1186/s13020-025-01060-x.

Lutein and Zeaxanthin Enhance, Whereas Oxidation, Fructosylation, and Low pH Damage High-Density Lipoprotein Biological Functionality.

Zheng J, Hong B, Agus J, Tang X, Klebaner N, Chen S Antioxidants (Basel). 2024; 13(5).

PMID: 38790721 PMC: 11118252. DOI: 10.3390/antiox13050616.

Metagenomic analysis of the intestinal microbiome reveals the potential mechanism involved in in treating schistosomiasis japonica in mice.

Chen H, Huang S, Zhao Y, Sun R, Wang J, Yao S Microbiol Spectr. 2024; 12(4):e0373523.

PMID: 38441977 PMC: 10986500. DOI: 10.1128/spectrum.03735-23.

Associations of fruit, whole grain, and total energy intakes with gut microbiome diversity and composition.

Wang Y, Zhang K, Dai L, Sun F, Wang D, Meng S Food Nutr Res. 2023; 67.

PMID: 38084154 PMC: 10710858. DOI: 10.29219/fnr.v67.9725.

Precision Nutrition and Cardiovascular Disease Risk Reduction: the Promise of High-Density Lipoproteins.

Hong B, Agus J, Tang X, Zheng J, Romo E, Lei S Curr Atheroscler Rep. 2023; 25(10):663-677.

PMID: 37702886 PMC: 10564829. DOI: 10.1007/s11883-023-01148-5.

References

Hwang I, Yoo K, Li H, Park O, Lee C, Choi J . Indole-3-propionic acid attenuates neuronal damage and oxidative stress in the ischemic hippocampus. J Neurosci Res. 2009; 87(9):2126-37. DOI: 10.1002/jnr.22030. View

Rey F, Faith J, Bain J, Muehlbauer M, Stevens R, Newgard C . Dissecting the in vivo metabolic potential of two human gut acetogens. J Biol Chem. 2010; 285(29):22082-90. PMC: 2903421. DOI: 10.1074/jbc.M110.117713. View

Ramirez-Farias C, Slezak K, Fuller Z, Duncan A, Holtrop G, Louis P . Effect of inulin on the human gut microbiota: stimulation of Bifidobacterium adolescentis and Faecalibacterium prausnitzii. Br J Nutr. 2008; 101(4):541-50. DOI: 10.1017/S0007114508019880. View

Jenkins D, Kendall C, Vuksan V, Vidgen E, Parker T, Faulkner D . Soluble fiber intake at a dose approved by the US Food and Drug Administration for a claim of health benefits: serum lipid risk factors for cardiovascular disease assessed in a randomized controlled crossover trial. Am J Clin Nutr. 2002; 75(5):834-9. DOI: 10.1093/ajcn/75.5.834. View

Shimada Y, Kinoshita M, Harada K, Mizutani M, Masahata K, Kayama H . Commensal bacteria-dependent indole production enhances epithelial barrier function in the colon. PLoS One. 2013; 8(11):e80604. PMC: 3835565. DOI: 10.1371/journal.pone.0080604. View

Chandalia M, Garg A, Lutjohann D, von Bergmann K, Grundy S, Brinkley L . Beneficial effects of high dietary fiber intake in patients with type 2 diabetes mellitus. N Engl J Med. 2000; 342(19):1392-8. DOI: 10.1056/NEJM200005113421903. View

Simo C, Garcia-Canas V . Dietary bioactive ingredients to modulate the gut microbiota-derived metabolite TMAO. New opportunities for functional food development. Food Funct. 2020; 11(8):6745-6776. DOI: 10.1039/d0fo01237h. View

Cani P, Neyrinck A, Fava F, Knauf C, Burcelin R, Tuohy K . Selective increases of bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia. Diabetologia. 2007; 50(11):2374-83. DOI: 10.1007/s00125-007-0791-0. View

Devika N, Raman K . Deciphering the metabolic capabilities of Bifidobacteria using genome-scale metabolic models. Sci Rep. 2019; 9(1):18222. PMC: 6890778. DOI: 10.1038/s41598-019-54696-9. View

10.

Negatu D, Gengenbacher M, Dartois V, Dick T . Indole Propionic Acid, an Unusual Antibiotic Produced by the Gut Microbiota, With Anti-inflammatory and Antioxidant Properties. Front Microbiol. 2020; 11:575586. PMC: 7652848. DOI: 10.3389/fmicb.2020.575586. View

11.

Ganapathy V, Thangaraju M, Prasad P, Martin P, Singh N . Transporters and receptors for short-chain fatty acids as the molecular link between colonic bacteria and the host. Curr Opin Pharmacol. 2013; 13(6):869-74. DOI: 10.1016/j.coph.2013.08.006. View

12.

Zhang C, Liu S, Solomon C, Hu F . Dietary fiber intake, dietary glycemic load, and the risk for gestational diabetes mellitus. Diabetes Care. 2006; 29(10):2223-30. DOI: 10.2337/dc06-0266. View

13.

Surampudi P, Enkhmaa B, Anuurad E, Berglund L . Lipid Lowering with Soluble Dietary Fiber. Curr Atheroscler Rep. 2016; 18(12):75. DOI: 10.1007/s11883-016-0624-z. View

14.

Zhang C, Derrien M, Levenez F, Brazeilles R, Ballal S, Kim J . Ecological robustness of the gut microbiota in response to ingestion of transient food-borne microbes. ISME J. 2016; 10(9):2235-45. PMC: 4989305. DOI: 10.1038/ismej.2016.13. View

15.

Day-Walsh P, Shehata E, Saha S, Savva G, Nemeckova B, Speranza J . The use of an in-vitro batch fermentation (human colon) model for investigating mechanisms of TMA production from choline, L-carnitine and related precursors by the human gut microbiota. Eur J Nutr. 2021; 60(7):3987-3999. PMC: 8437865. DOI: 10.1007/s00394-021-02572-6. View

16.

Tan J, McKenzie C, Potamitis M, Thorburn A, Mackay C, Macia L . The role of short-chain fatty acids in health and disease. Adv Immunol. 2014; 121:91-119. DOI: 10.1016/B978-0-12-800100-4.00003-9. View

17.

Tao Z, Raffel R, Souid A, Goodisman J . Kinetic studies on enzyme-catalyzed reactions: oxidation of glucose, decomposition of hydrogen peroxide and their combination. Biophys J. 2009; 96(7):2977-88. PMC: 2711289. DOI: 10.1016/j.bpj.2008.11.071. View

18.

Grooms K, Ommerborn M, Pham D, Djousse L, Clark C . Dietary fiber intake and cardiometabolic risks among US adults, NHANES 1999-2010. Am J Med. 2013; 126(12):1059-67.e1-4. PMC: 3865784. DOI: 10.1016/j.amjmed.2013.07.023. View

19.

Audet-Delage Y, Villeneuve L, Gregoire J, Plante M, Guillemette C . Identification of Metabolomic Biomarkers for Endometrial Cancer and Its Recurrence after Surgery in Postmenopausal Women. Front Endocrinol (Lausanne). 2018; 9:87. PMC: 5857535. DOI: 10.3389/fendo.2018.00087. View

20.

Healey G, Murphy R, Butts C, Brough L, Whelan K, Coad J . Habitual dietary fibre intake influences gut microbiota response to an inulin-type fructan prebiotic: a randomised, double-blind, placebo-controlled, cross-over, human intervention study. Br J Nutr. 2018; 119(2):176-189. DOI: 10.1017/S0007114517003440. View