Oligoclonal T-cell Expansion in a Patient with Bone Marrow Failure After CD19 CAR-T Therapy for Richter-transformed DLBCL

Overview

Journal Blood

Publisher Elsevier

Specialty Hematology

Date 2022 Jul 1

PMID 35776908

Authors

Kai Rejeski

Zhijie Wu

Viktoria Blumenberg

Wolfgang G Kunz

Susanna Muller

Sachiko Kajigaya

Shouguo Gao

Veit L Bucklein

Lisa Frolich

Christian Schmidt

Michael von Bergwelt-Baildon

Xingmin Feng

Neal S Young

Marion Subklewe

Affiliations

Soon will be listed here.

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References

Fried S, Avigdor A, Bielorai B, Meir A, Besser M, Schachter J . Early and late hematologic toxicity following CD19 CAR-T cells. Bone Marrow Transplant. 2019; 54(10):1643-1650. DOI: 10.1038/s41409-019-0487-3. View

Stamatopoulos K, Papadaki T, Pontikoglou C, Athanasiadou I, Stavroyianni N, Bux J . Lymphocyte subpopulation imbalances, bone marrow hematopoiesis and histopathology in rituximab-treated lymphoma patients with late-onset neutropenia. Leukemia. 2008; 22(7):1446-9. DOI: 10.1038/sj.leu.2405077. View

Cheson B, Fisher R, Barrington S, Cavalli F, Schwartz L, Zucca E . Recommendations for initial evaluation, staging, and response assessment of Hodgkin and non-Hodgkin lymphoma: the Lugano classification. J Clin Oncol. 2014; 32(27):3059-68. PMC: 4979083. DOI: 10.1200/JCO.2013.54.8800. View

Fajgenbaum D, June C . Cytokine Storm. N Engl J Med. 2020; 383(23):2255-2273. PMC: 7727315. DOI: 10.1056/NEJMra2026131. View

Dunleavy K, Tay K, Wilson W . Rituximab-associated neutropenia. Semin Hematol. 2010; 47(2):180-6. PMC: 7304500. DOI: 10.1053/j.seminhematol.2010.01.009. View

Rejeski K, Perez A, Sesques P, Hoster E, Berger C, Jentzsch L . CAR-HEMATOTOX: a model for CAR T-cell-related hematologic toxicity in relapsed/refractory large B-cell lymphoma. Blood. 2021; 138(24):2499-2513. PMC: 8893508. DOI: 10.1182/blood.2020010543. View

Jain T, Knezevic A, Pennisi M, Chen Y, Ruiz J, Purdon T . Hematopoietic recovery in patients receiving chimeric antigen receptor T-cell therapy for hematologic malignancies. Blood Adv. 2020; 4(15):3776-3787. PMC: 7422135. DOI: 10.1182/bloodadvances.2020002509. View

Young N . Aplastic Anemia. N Engl J Med. 2018; 379(17):1643-1656. PMC: 6467577. DOI: 10.1056/NEJMra1413485. View

Chen J, Desierto M, Feng X, Biancotto A, Young N . Immune-mediated bone marrow failure in C57BL/6 mice. Exp Hematol. 2015; 43(4):256-67. PMC: 4378590. DOI: 10.1016/j.exphem.2014.12.006. View

10.

Roessner P, Seiffert M . T-cells in chronic lymphocytic leukemia: Guardians or drivers of disease?. Leukemia. 2020; 34(8):2012-2024. PMC: 8318881. DOI: 10.1038/s41375-020-0873-2. View

11.

de Back T, Kater A, Tonino S . Autoimmune cytopenias in chronic lymphocytic leukemia: a concise review and treatment recommendations. Expert Rev Hematol. 2018; 11(8):613-624. DOI: 10.1080/17474086.2018.1489720. View

12.

Gao S, Wu Z, Arnold B, Diamond C, Batchu S, Giudice V . Single-cell RNA sequencing coupled to TCR profiling of large granular lymphocyte leukemia T cells. Nat Commun. 2022; 13(1):1982. PMC: 9001664. DOI: 10.1038/s41467-022-29175-x. View

13.

Rejeski K, Perez A, Iacoboni G, Penack O, Bucklein V, Jentzsch L . The CAR-HEMATOTOX risk-stratifies patients for severe infections and disease progression after CD19 CAR-T in R/R LBCL. J Immunother Cancer. 2022; 10(5). PMC: 9114843. DOI: 10.1136/jitc-2021-004475. View

14.

Feng X, Scheinberg P, Wu C, Samsel L, Nunez O, Prince C . Cytokine signature profiles in acquired aplastic anemia and myelodysplastic syndromes. Haematologica. 2010; 96(4):602-6. PMC: 3069238. DOI: 10.3324/haematol.2010.030536. View

15.

Giudice V, Feng X, Lin Z, Hu W, Zhang F, Qiao W . Deep sequencing and flow cytometric characterization of expanded effector memory CD8CD57 T cells frequently reveals T-cell receptor Vβ oligoclonality and CDR3 homology in acquired aplastic anemia. Haematologica. 2018; 103(5):759-769. PMC: 5927970. DOI: 10.3324/haematol.2017.176701. View

16.

Iwata M, Graf L, Awaya N, Torok-Storb B . Functional interleukin-7 receptors (IL-7Rs) are expressed by marrow stromal cells: binding of IL-7 increases levels of IL-6 mRNA and secreted protein. Blood. 2002; 100(4):1318-25. DOI: 10.1182/blood-2002-01-0062. View

17.

Rejeski K, Kunz W, Rudelius M, Bucklein V, Blumenberg V, Schmidt C . Severe Candida glabrata pancolitis and fatal Aspergillus fumigatus pulmonary infection in the setting of bone marrow aplasia after CD19-directed CAR T-cell therapy - a case report. BMC Infect Dis. 2021; 21(1):121. PMC: 7841988. DOI: 10.1186/s12879-020-05755-4. View

18.

Hill J, Li D, Hay K, Green M, Cherian S, Chen X . Infectious complications of CD19-targeted chimeric antigen receptor-modified T-cell immunotherapy. Blood. 2017; 131(1):121-130. PMC: 5755046. DOI: 10.1182/blood-2017-07-793760. View

19.

Juluri K, Wu Q, Voutsinas J, Hou J, Hirayama A, Mullane E . Severe cytokine release syndrome is associated with hematologic toxicity following CD19 CAR T-cell therapy. Blood Adv. 2021; 6(7):2055-2068. PMC: 9006285. DOI: 10.1182/bloodadvances.2020004142. View

20.

Chen J, Ellison F, Eckhaus M, Smith A, Keyvanfar K, Calado R . Minor antigen h60-mediated aplastic anemia is ameliorated by immunosuppression and the infusion of regulatory T cells. J Immunol. 2007; 178(7):4159-68. DOI: 10.4049/jimmunol.178.7.4159. View