Environmental Influences on Childhood Allergies and Asthma - The Farm Effect

Overview

Journal Pediatr Allergy Immunol

Specialty Pediatrics

Date 2022 Jun 27

PMID 35754122

Authors

Remo Frei

Kristina Heye

Caroline Roduit

Affiliations

Soon will be listed here.

Abstract

Asthma and allergies are major health problems and exert an enormous socioeconomic burden. Besides genetic predisposition, environmental factors play a crucial role in the development of these diseases in childhood. Multiple worldwide epidemiological studies have shown that children growing up on farms are immune to allergic diseases and asthma. Farm-related exposures shape children's immune homeostasis, via mediators such as N-glycolylneuraminic acid or arabinogalactan, or by diverse environmental microbes. Moreover, nutritional factors, such as breastfeeding or farm milk and food diversity, inducing short-chain fatty acids-producing bacteria in the intestine, contribute to farm-related effects. All farm-related exposures induce an anti-inflammatory response of the innate immunity and increase the differentiation of regulatory T cells and T helper cell type 1. A better understanding of the components of the farm environment, that are protective to the development of allergy and asthma, and their underlying mechanisms, will help to develop new strategies for the prevention of allergy and asthma.

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References

Zmora N, Suez J, Elinav E . You are what you eat: diet, health and the gut microbiota. Nat Rev Gastroenterol Hepatol. 2018; 16(1):35-56. DOI: 10.1038/s41575-018-0061-2. View

Frei R, Roduit C, Bieli C, Loeliger S, Waser M, Scheynius A . Expression of genes related to anti-inflammatory pathways are modified among farmers' children. PLoS One. 2014; 9(3):e91097. PMC: 3946278. DOI: 10.1371/journal.pone.0091097. View

Peters M, Guidato P, Peters K, Megger D, Sitek B, Classen B . Allergy-Protective Arabinogalactan Modulates Human Dendritic Cells via C-Type Lectins and Inhibition of NF-κB. J Immunol. 2016; 196(4):1626-35. DOI: 10.4049/jimmunol.1502178. View

Orivuori L, Loss G, Roduit C, Dalphin J, Depner M, Genuneit J . Soluble immunoglobulin A in breast milk is inversely associated with atopic dermatitis at early age: the PASTURE cohort study. Clin Exp Allergy. 2013; 44(1):102-12. DOI: 10.1111/cea.12199. View

Schuijs M, Willart M, Vergote K, Gras D, Deswarte K, Ege M . Farm dust and endotoxin protect against allergy through A20 induction in lung epithelial cells. Science. 2015; 349(6252):1106-10. DOI: 10.1126/science.aac6623. View

Roduit C, Wohlgensinger J, Frei R, Bitter S, Bieli C, Loeliger S . Prenatal animal contact and gene expression of innate immunity receptors at birth are associated with atopic dermatitis. J Allergy Clin Immunol. 2010; 127(1):179-85, 185.e1. DOI: 10.1016/j.jaci.2010.10.010. View

Deckers J, Marsland B, von Mutius E . Protection against allergies: Microbes, immunity, and the farming effect. Eur J Immunol. 2021; 51(10):2387-2398. DOI: 10.1002/eji.202048938. View

Midodzi W, Rowe B, Majaesic C, Senthilselvan A . Reduced risk of physician-diagnosed asthma among children dwelling in a farming environment. Respirology. 2007; 12(5):692-9. DOI: 10.1111/j.1440-1843.2007.01134.x. View

Frei R, Lauener R, Crameri R, OMahony L . Microbiota and dietary interactions: an update to the hygiene hypothesis?. Allergy. 2012; 67(4):451-61. DOI: 10.1111/j.1398-9995.2011.02783.x. View

10.

Ege M, Frei R, Bieli C, Schram-Bijkerk D, Waser M, Benz M . Not all farming environments protect against the development of asthma and wheeze in children. J Allergy Clin Immunol. 2007; 119(5):1140-7. DOI: 10.1016/j.jaci.2007.01.037. View

11.

Kaario H, Huttunen K, Karvonen A, Schaub B, von Mutius E, Pekkanen J . Exposure to a farm environment is associated with T helper 1 and regulatory cytokines at age 4.5 years. Clin Exp Allergy. 2015; 46(1):71-7. DOI: 10.1111/cea.12636. View

12.

Loss G, Bitter S, Wohlgensinger J, Frei R, Roduit C, Genuneit J . Prenatal and early-life exposures alter expression of innate immunity genes: the PASTURE cohort study. J Allergy Clin Immunol. 2012; 130(2):523-30.e9. DOI: 10.1016/j.jaci.2012.05.049. View

13.

Pfefferle P, Buchele G, Blumer N, Roponen M, Ege M, Krauss-Etschmann S . Cord blood cytokines are modulated by maternal farming activities and consumption of farm dairy products during pregnancy: the PASTURE Study. J Allergy Clin Immunol. 2009; 125(1):108-15.e1-3. DOI: 10.1016/j.jaci.2009.09.019. View

14.

von Mutius E, Vercelli D . Farm living: effects on childhood asthma and allergy. Nat Rev Immunol. 2010; 10(12):861-8. DOI: 10.1038/nri2871. View

15.

Roduit C, Frei R, Ferstl R, Loeliger S, Westermann P, Rhyner C . High levels of butyrate and propionate in early life are associated with protection against atopy. Allergy. 2018; 74(4):799-809. DOI: 10.1111/all.13660. View

16.

Rook G . Hygiene hypothesis and autoimmune diseases. Clin Rev Allergy Immunol. 2011; 42(1):5-15. DOI: 10.1007/s12016-011-8285-8. View

17.

Wickens K, Lane J, Fitzharris P, Siebers R, Riley G, Douwes J . Farm residence and exposures and the risk of allergic diseases in New Zealand children. Allergy. 2002; 57(12):1171-9. DOI: 10.1034/j.1398-9995.2002.t01-1-23644.x. View

18.

Lee-Sarwar K, Lasky-Su J, Kelly R, Litonjua A, Weiss S . Gut Microbial-Derived Metabolomics of Asthma. Metabolites. 2020; 10(3. PMC: 7142494. DOI: 10.3390/metabo10030097. View

19.

Trompette A, Gollwitzer E, Yadava K, Sichelstiel A, Sprenger N, Ngom-Bru C . Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis. Nat Med. 2014; 20(2):159-66. DOI: 10.1038/nm.3444. View

20.

Eiwegger T, Hung L, San Diego K, OMahony L, Upton J . Recent developments and highlights in food allergy. Allergy. 2019; 74(12):2355-2367. DOI: 10.1111/all.14082. View