Functional Magnetic Resonance Imaging and Obesity-Novel Ways to Seen the Unseen

Overview

Journal J Clin Med

Specialty General Medicine

Date 2022 Jun 24

PMID 35743630

Authors

Anna Drelich-Zbroja

Malgorzata Matuszek

Michal Kaczor

Maryla Kuczynska

Affiliations

Soon will be listed here.

Abstract

Obesity remains a pandemic of the 21st century. While there are many causes of obesity and potential treatments that are currently known, source data indicate that the number of patients is constantly increasing. Neural mechanisms have become the subject of research and there has been an introduction of functional magnetic resonance imaging in obesity-associated altered neural signaling. Functional magnetic resonance imaging has been established as the gold standard in the assessment of neuronal functions related to nutrition. Thanks to this, it has become possible to delineate those regions of the brain that show altered activity in obese individuals. An integrative review of the literature was conducted using the keywords ""functional neuroimaging" OR "functional magnetic resonance "OR "fmri" and "obesity" and "reward circuit and obesity" in PubMed and Google Scholar databases from 2017 through May 2022. Results in English and using functional magnetic resonance imaging to evaluate brain response to diet and food images were identified. The results from functional magnetic resonance imaging may help to identify relationships between neuronal mechanisms and causes of obesity. Furthermore, they may provide a substrate for etiology-based treatment and provide new opportunities for the development of obesity pharmacotherapy.

Citing Articles

Obesity, Cardiovascular and Neurodegenerative Diseases: Potential Common Mechanisms.

Kunes J, Hojna S, Mrazikova L, Montezano A, Touyz R, Maletinska L Physiol Res. 2023; 72(Suppl 2):S73-S90.

PMID: 37565414 PMC: 10660578. DOI: 10.33549/physiolres.935109.

Current Insights into the Potential Role of fMRI in Discovering the Mechanisms Underlying Obesity.

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PMID: 37445414 PMC: 10342891. DOI: 10.3390/jcm12134379.

References

Langguth B, Schecklmann M, Lehner A, Landgrebe M, Poeppl T, Kreuzer P . Neuroimaging and neuromodulation: complementary approaches for identifying the neuronal correlates of tinnitus. Front Syst Neurosci. 2012; 6:15. PMC: 3321434. DOI: 10.3389/fnsys.2012.00015. View

Veronese N, Facchini S, Stubbs B, Luchini C, Solmi M, Manzato E . Weight loss is associated with improvements in cognitive function among overweight and obese people: A systematic review and meta-analysis. Neurosci Biobehav Rev. 2016; 72:87-94. DOI: 10.1016/j.neubiorev.2016.11.017. View

Farr O, Li C, Mantzoros C . Central nervous system regulation of eating: Insights from human brain imaging. Metabolism. 2016; 65(5):699-713. PMC: 4834455. DOI: 10.1016/j.metabol.2016.02.002. View

Kroll D, Feldman D, Biesecker C, McPherson K, Manza P, Joseph P . Neuroimaging of Sex/Gender Differences in Obesity: A Review of Structure, Function, and Neurotransmission. Nutrients. 2020; 12(7). PMC: 7400469. DOI: 10.3390/nu12071942. View

Prickett C, Brennan L, Stolwyk R . Examining the relationship between obesity and cognitive function: a systematic literature review. Obes Res Clin Pract. 2015; 9(2):93-113. DOI: 10.1016/j.orcp.2014.05.001. View

Lee P, Dixon J . Food for Thought: Reward Mechanisms and Hedonic Overeating in Obesity. Curr Obes Rep. 2017; 6(4):353-361. DOI: 10.1007/s13679-017-0280-9. View

Wijngaarden M, Veer I, Rombouts S, van Buchem M, Willems van Dijk K, Pijl H . Obesity is marked by distinct functional connectivity in brain networks involved in food reward and salience. Behav Brain Res. 2015; 287:127-34. DOI: 10.1016/j.bbr.2015.03.016. View

Mier W, Mier D . Advantages in functional imaging of the brain. Front Hum Neurosci. 2015; 9:249. PMC: 4436574. DOI: 10.3389/fnhum.2015.00249. View

Nguyen J, Killcross A, Jenkins T . Obesity and cognitive decline: role of inflammation and vascular changes. Front Neurosci. 2014; 8:375. PMC: 4237034. DOI: 10.3389/fnins.2014.00375. View

10.

Gendelis S, Inbar D, Inbar K, Mesner S, Kupchik Y . Metaplasticity in the Ventral Pallidum as a Potential Marker for the Propensity to Gain Weight in Chronic High-Calorie Diet. J Neurosci. 2020; 40(50):9725-9735. PMC: 7726535. DOI: 10.1523/JNEUROSCI.1809-20.2020. View

11.

Denis R, Joly-Amado A, Webber E, Langlet F, Schaeffer M, Padilla S . Palatability Can Drive Feeding Independent of AgRP Neurons. Cell Metab. 2015; 22(4):646-57. PMC: 5024566. DOI: 10.1016/j.cmet.2015.07.011. View

12.

Woods S, DAlessio D . Central control of body weight and appetite. J Clin Endocrinol Metab. 2008; 93(11 Suppl 1):S37-50. PMC: 2585760. DOI: 10.1210/jc.2008-1630. View

13.

Demos K, Heatherton T, Kelley W . Individual differences in nucleus accumbens activity to food and sexual images predict weight gain and sexual behavior. J Neurosci. 2012; 32(16):5549-52. PMC: 3377379. DOI: 10.1523/JNEUROSCI.5958-11.2012. View

14.

Riederer J, Shott M, DeGuzman M, Pryor T, Frank G . Understanding Neuronal Architecture in Obesity through Analysis of White Matter Connection Strength. Front Hum Neurosci. 2016; 10:271. PMC: 4893484. DOI: 10.3389/fnhum.2016.00271. View

15.

Zhou Y, Chi J, Lv W, Wang Y . Obesity and diabetes as high-risk factors for severe coronavirus disease 2019 (Covid-19). Diabetes Metab Res Rev. 2020; 37(2):e3377. PMC: 7361201. DOI: 10.1002/dmrr.3377. View

16.

Kim A, Shim J, Choi H, Baek H . Comparison of volumetric and shape changes of subcortical structures based on 3-dimensional image between obesity and normal-weighted subjects using 3.0 T MRI. J Clin Neurosci. 2020; 73:280-287. DOI: 10.1016/j.jocn.2019.12.052. View

17.

Althubeati S, Avery A, Tench C, Lobo D, Salter A, Eldeghaidy S . Mapping brain activity of gut-brain signaling to appetite and satiety in healthy adults: A systematic review and functional neuroimaging meta-analysis. Neurosci Biobehav Rev. 2022; 136:104603. PMC: 9096878. DOI: 10.1016/j.neubiorev.2022.104603. View

18.

Alhabeeb H, AlFaiz A, Kutbi E, AlShahrani D, Alsuhail A, Alrajhi S . Gut Hormones in Health and Obesity: The Upcoming Role of Short Chain Fatty Acids. Nutrients. 2021; 13(2). PMC: 7911102. DOI: 10.3390/nu13020481. View

19.

Raji C, Ho A, Parikshak N, Becker J, Lopez O, Kuller L . Brain structure and obesity. Hum Brain Mapp. 2009; 31(3):353-64. PMC: 2826530. DOI: 10.1002/hbm.20870. View

20.

Maayan L, Hoogendoorn C, Sweat V, Convit A . Disinhibited eating in obese adolescents is associated with orbitofrontal volume reductions and executive dysfunction. Obesity (Silver Spring). 2011; 19(7):1382-7. PMC: 3124611. DOI: 10.1038/oby.2011.15. View