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Antioxidant, Anti-Inflammatory and Cytotoxic Activity of Phenolic Compound Family Extracted from Raspberries (): A General Review

Abstract

Raspberries () possess a wide phenolic family profile; this serves the role of self-protection for the plant. Interest in these compounds have significantly increased, since they have been classified as nutraceuticals due to the positive health effects provided to consumers. Extensive chemical, in vitro and in vivo studies have been performed to prove and validate these benefits and their possible applications as an aid when treating several chronic degenerative diseases, characterized by oxidative stress and an inflammatory response. While many diseases could be co-adjuvanted by the intake of these phenolic compounds, this review will mainly discuss their effects on cancer. Anthocyanins and ellagitannins are known to provide a major antioxidant capacity in raspberries. The aim of this review is to summarize the current knowledge concerning the phenolic compound family of raspberries, and topics discussed include their characterization, biosynthesis, bioavailability, cytotoxicity, antioxidant and anti-inflammatory activities.

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References
1.
Krol M, Kepinska M . Human Nitric Oxide Synthase-Its Functions, Polymorphisms, and Inhibitors in the Context of Inflammation, Diabetes and Cardiovascular Diseases. Int J Mol Sci. 2020; 22(1). PMC: 7793075. DOI: 10.3390/ijms22010056. View

2.
Bontpart T, Marlin T, Vialet S, Guiraud J, Pinasseau L, Meudec E . Two shikimate dehydrogenases, VvSDH3 and VvSDH4, are involved in gallic acid biosynthesis in grapevine. J Exp Bot. 2016; 67(11):3537-50. PMC: 4892741. DOI: 10.1093/jxb/erw184. View

3.
Agullo V, Villano D, Garcia-Viguera C, Dominguez-Perles R . Anthocyanin Metabolites in Human Urine after the Intake of New Functional Beverages. Molecules. 2020; 25(2). PMC: 7024541. DOI: 10.3390/molecules25020371. View

4.
Bibi S, Du M, Zhu M . Dietary Red Raspberry Reduces Colorectal Inflammation and Carcinogenic Risk in Mice with Dextran Sulfate Sodium-Induced Colitis. J Nutr. 2018; 148(5):667-674. PMC: 7263837. DOI: 10.1093/jn/nxy007. View

5.
Nejat N, Mantri N . Plant Immune System: Crosstalk Between Responses to Biotic and Abiotic Stresses the Missing Link in Understanding Plant Defence. Curr Issues Mol Biol. 2017; 23:1-16. DOI: 10.21775/cimb.023.001. View