Cancer-related Inflammation: Common Themes and Therapeutic Opportunities

Overview

Journal Semin Cancer Biol

Specialty Oncology

Date 2012 Jan 3

PMID 22210179

Citations 329

Authors

Frances R Balkwill

Alberto Mantovani

Affiliations

Soon will be listed here.

Abstract

Inflammatory cells and mediators are an essential component of the tumor microenvironment. Inflammatory circuits can differ considerably in different tumors in terms of cellular and cytokine networks and molecular drivers. However, macrophages are a common and fundamental component of cancer promoting inflammation. Drivers of macrophage functional orientation include tumor cells, cancer-associated fibroblasts, T cells and B cells. Dissection of the diversity of cancer-related inflammation is instrumental to the design of therapeutic approaches that target cancer-related inflammation.

Citing Articles

Morphofunctional changes in the immune system in colitis-associated colorectal cancer in tolerant and susceptible to hypoxia mice.

Dzhalilova D, Silina M, Kosyreva A, Fokichev N, Makarova O PeerJ. 2025; 13:e19024.

PMID: 40028198 PMC: 11869898. DOI: 10.7717/peerj.19024.

Understanding the role of nerves in head and neck cancers - a review.

Rutkowski K, Gola M, Godlewski J, Starzynska A, Marvaso G, Mastroleo F Oncol Rev. 2025; 18:1514004.

PMID: 39906323 PMC: 11791411. DOI: 10.3389/or.2024.1514004.

Hypnosis Sedation Used in Breast Oncologic Surgery Significantly Decreases Perioperative Inflammatory Reaction.

Berliere M, Roelants F, Duhoux F, Gerday A, Piette N, Lacroix C Cancers (Basel). 2025; 17(1.

PMID: 39796678 PMC: 11718863. DOI: 10.3390/cancers17010049.

CD3+CD4-CD8- Double-Negative Lymphocytes Are Increased in the Aqueous Humor of Patients with Retinitis Pigmentosa: Their Possible Role in Mediating Inflammation.

Bacherini D, Maggi L, Faraldi F, Sodi A, Vannozzi L, Mazzoni A Int J Mol Sci. 2024; 25(23).

PMID: 39684872 PMC: 11641927. DOI: 10.3390/ijms252313163.

Expression of senescence-related CD161 promotes extranodal NK/T cell lymphoma by affecting T cell phenotype and cell cycle.

Jin C, Li X, Zhang C Mol Med. 2024; 30(1):230.

PMID: 39580409 PMC: 11585959. DOI: 10.1186/s10020-024-00969-7.