Bile Acid Regulates Mononuclear Phagocytes and T Helper 17 Cells to Control in the Intestine

Overview

Journal J Fungi (Basel)

Date 2022 Jun 23

PMID 35736093

Authors

Abhishek Datta

Juan F Hernandez-Franco

SungTae Park

Matthew R Olson

Harm HogenEsch

Shankar Thangamani

Affiliations

Soon will be listed here.

Abstract

Invasive () infections often arise from the intestine and cause life-threatening infections in immunocompromised individuals. The role of gut commensal microbiota, metabolites, and host factors in the regulation of CA colonization in the intestine is poorly understood. Previous findings from our lab indicate that taurocholic acid (), a major bile acid present in the intestine, promotes CA colonization and dissemination. Here, we report that oral administration of TCA to CA-infected mice significantly decreased the number of mononuclear phagocytes and CD4+ IL17A+ T helper 17 cells that play a critical role in controlling CA in the intestine. Collectively, our results indicate that TCA modulates mucosal innate and adaptive immune responses to promote CA colonization in the intestine.

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