Familial Risk of Postpartum Depression

Overview

Journal Acta Psychiatr Scand

Specialty Psychiatry

Date 2022 Jun 22

PMID 35731191

Authors

Marie-Louise H Rasmussen

Gry J Poulsen

Jan Wohlfahrt

Poul Videbech

Mads Melbye

Affiliations

Soon will be listed here.

Abstract

Objective: Many psychiatric diseases have a strong familial aggregation, but it is unknown whether postpartum depression (PPD) without prior psychiatric history aggregates in families.

Methods: Based on Danish national registers, we constructed a cohort with information on 848,544 singleton deliveries (1996-2017). Women with an episode of PPD were defined as having used antidepressant medication and/or had a hospital contact for depression within 6 months after delivery. Those with psychiatric history prior to the delivery were excluded. We estimated relative risk (RR) of PPD, comparing women with female relatives with and without PPD history, respectively.

Results: Overall, women with a PPD history in female blood relatives had themselves a higher risk of PPD (RR = 1.64, 95% CI 1.16-2.34). Having the first-degree female relative with PPD history was associated with a more than 2.5 times (RR = 2.65, 95% CI 1.79-3.91) increased risk of PPD. However, having the second/third-degree female relative and/or a female non-blood relative with PPD history did not increase the woman's own risk of PPD (RR = 0.58, 95% CI 0.26-1.28, RR = 1.09, 95% CI 0.83-1.44).

Conclusion: Postpartum depression aggregates in families with no other psychiatric history, but the findings do not support a strong genetic trait as a major cause. Other possible mechanisms are shared environment and/or health-seeking behavior in close relationships.

Citing Articles

Correlation of lifestyle behaviors during pregnancy with postpartum depression status of puerpera in the rural areas of South China.

Ding Y, Li G, Shi X, Wang M, Peng Y, Deng H Front Public Health. 2024; 11:1304226.

PMID: 38192564 PMC: 10773618. DOI: 10.3389/fpubh.2023.1304226.

Familial risk of postpartum depression.

Rasmussen M, Poulsen G, Wohlfahrt J, Videbech P, Melbye M Acta Psychiatr Scand. 2022; 146(4):340-349.

PMID: 35731191 PMC: 9796634. DOI: 10.1111/acps.13465.

References

Putnam K, Wilcox M, Robertson-Blackmore E, Sharkey K, Bergink V, Munk-Olsen T . Clinical phenotypes of perinatal depression and time of symptom onset: analysis of data from an international consortium. Lancet Psychiatry. 2017; 4(6):477-485. PMC: 5836292. DOI: 10.1016/S2215-0366(17)30136-0. View

Engineer N, Darwin L, Nishigandh D, Ngianga-Bakwin K, Smith S, Grammatopoulos D . Association of glucocorticoid and type 1 corticotropin-releasing hormone receptors gene variants and risk for depression during pregnancy and post-partum. J Psychiatr Res. 2013; 47(9):1166-73. DOI: 10.1016/j.jpsychires.2013.05.003. View

Nielsen Forman D, Videbech P, Hedegaard M, Dalby Salvig J, Secher N . Postpartum depression: identification of women at risk. BJOG. 2000; 107(10):1210-7. DOI: 10.1111/j.1471-0528.2000.tb11609.x. View

Pinsonneault J, Sullivan D, Sadee W, Soares C, Hampson E, Steiner M . Association study of the estrogen receptor gene ESR1 with postpartum depression--a pilot study. Arch Womens Ment Health. 2013; 16(6):499-509. PMC: 3833886. DOI: 10.1007/s00737-013-0373-8. View

Comasco E, Sylven S, Papadopoulos F, Oreland L, Sundstrom-Poromaa I, Skalkidou A . Postpartum depressive symptoms and the BDNF Val66Met functional polymorphism: effect of season of delivery. Arch Womens Ment Health. 2011; 14(6):453-63. DOI: 10.1007/s00737-011-0239-x. View

Comasco E, Sylven S, Papadopoulos F, Sundstrom-Poromaa I, Oreland L, Skalkidou A . Postpartum depression symptoms: a case-control study on monoaminergic functional polymorphisms and environmental stressors. Psychiatr Genet. 2010; 21(1):19-28. DOI: 10.1097/YPG.0b013e328341a3c1. View

. Biological insights from 108 schizophrenia-associated genetic loci. Nature. 2014; 511(7510):421-7. PMC: 4112379. DOI: 10.1038/nature13595. View

Jonas W, Mileva-Seitz V, Girard A, Bisceglia R, Kennedy J, Sokolowski M . Genetic variation in oxytocin rs2740210 and early adversity associated with postpartum depression and breastfeeding duration. Genes Brain Behav. 2013; 12(7):681-94. DOI: 10.1111/gbb.12069. View

Treloar S, Martin N, Bucholz K, Madden P, Heath A . Genetic influences on post-natal depressive symptoms: findings from an Australian twin sample. Psychol Med. 1999; 29(3):645-54. DOI: 10.1017/s0033291799008387. View

10.

Kendler K, Davis C, Kessler R . The familial aggregation of common psychiatric and substance use disorders in the National Comorbidity Survey: a family history study. Br J Psychiatry. 1997; 170:541-8. DOI: 10.1192/bjp.170.6.541. View

11.

Mehta D, Grewen K, Pearson B, Wani S, Wallace L, Henders A . Genome-wide gene expression changes in postpartum depression point towards an altered immune landscape. Transl Psychiatry. 2021; 11(1):155. PMC: 7933180. DOI: 10.1038/s41398-021-01270-5. View

12.

Forty L, Jones L, Macgregor S, Caesar S, Cooper C, Hough A . Familiality of postpartum depression in unipolar disorder: results of a family study. Am J Psychiatry. 2006; 163(9):1549-53. DOI: 10.1176/ajp.2006.163.9.1549. View

13.

Howard D, Adams M, Clarke T, Hafferty J, Gibson J, Shirali M . Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions. Nat Neurosci. 2019; 22(3):343-352. PMC: 6522363. DOI: 10.1038/s41593-018-0326-7. View

14.

Fahim S, van Duijn C, Baker F, Launer L, Breteler M, Schudel W . A study of familial aggregation of depression, dementia and Parkinson's disease. Eur J Epidemiol. 1998; 14(3):233-8. DOI: 10.1023/a:1007488902983. View

15.

Rasmussen M, Poulsen G, Wohlfahrt J, Videbech P, Melbye M . Familial risk of postpartum depression. Acta Psychiatr Scand. 2022; 146(4):340-349. PMC: 9796634. DOI: 10.1111/acps.13465. View

16.

Gavin N, Gaynes B, Lohr K, Meltzer-Brody S, Gartlehner G, Swinson T . Perinatal depression: a systematic review of prevalence and incidence. Obstet Gynecol. 2005; 106(5 Pt 1):1071-83. DOI: 10.1097/01.AOG.0000183597.31630.db. View

17.

Figueiredo F, Parada A, de Araujo L, Silva Jr W, Del-Ben C . The Influence of genetic factors on peripartum depression: A systematic review. J Affect Disord. 2014; 172:265-73. DOI: 10.1016/j.jad.2014.10.016. View

18.

Chou I, Kuo C, Huang Y, Grainge M, Valdes A, See L . Familial Aggregation and Heritability of Schizophrenia and Co-aggregation of Psychiatric Illnesses in Affected Families. Schizophr Bull. 2016; 43(5):1070-1078. PMC: 5581894. DOI: 10.1093/schbul/sbw159. View

19.

Payne J, Maguire J . Pathophysiological mechanisms implicated in postpartum depression. Front Neuroendocrinol. 2018; 52:165-180. PMC: 6370514. DOI: 10.1016/j.yfrne.2018.12.001. View

20.

Doornbos B, Dijck-Brouwer D, Kema I, Tanke M, van Goor S, Muskiet F . The development of peripartum depressive symptoms is associated with gene polymorphisms of MAOA, 5-HTT and COMT. Prog Neuropsychopharmacol Biol Psychiatry. 2009; 33(7):1250-4. DOI: 10.1016/j.pnpbp.2009.07.013. View