Structure of Human NTCP Reveals the Basis of Recognition and Sodium-driven Transport of Bile Salts into the Liver

Overview

Journal Cell Res

Specialty Cell Biology

Date 2022 Jun 21

PMID 35726088

Authors

Hongtao Liu

Rossitza N Irobalieva

Rose Bang-Sorensen

Kamil Nosol

Somnath Mukherjee

Parth Agrawal

Bruno Stieger

Anthony A Kossiakoff

Kaspar P Locher

Affiliations

Soon will be listed here.

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References

Jani M, Beery E, Heslop T, Toth B, Jagota B, Kis E . Kinetic characterization of bile salt transport by human NTCP (SLC10A1). Toxicol In Vitro. 2017; 46:189-193. DOI: 10.1016/j.tiv.2017.10.012. View

Yan H, Zhong G, Xu G, He W, Jing Z, Gao Z . Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus. Elife. 2012; 1:e00049. PMC: 3485615. DOI: 10.7554/eLife.00049. View

Bae M, Cassilly C, Liu X, Park S, Tusi B, Chen X . Akkermansia muciniphila phospholipid induces homeostatic immune responses. Nature. 2022; 608(7921):168-173. PMC: 9328018. DOI: 10.1038/s41586-022-04985-7. View

Lowjaga K, Kirstgen M, Muller S, Goldmann N, Lehmann F, Glebe D . Long-term -inhibition of the hepatitis B and D virus receptor NTCP by taurolithocholic acid. Am J Physiol Gastrointest Liver Physiol. 2020; 320(1):G66-G80. DOI: 10.1152/ajpgi.00263.2020. View

Urban S, Bartenschlager R, Kubitz R, Zoulim F . Strategies to inhibit entry of HBV and HDV into hepatocytes. Gastroenterology. 2014; 147(1):48-64. DOI: 10.1053/j.gastro.2014.04.030. View

Goutam K, Ielasi F, Pardon E, Steyaert J, Reyes N . Structural basis of sodium-dependent bile salt uptake into the liver. Nature. 2022; 606(7916):1015-1020. PMC: 9242856. DOI: 10.1038/s41586-022-04723-z. View

Doring B, Lutteke T, Geyer J, Petzinger E . The SLC10 carrier family: transport functions and molecular structure. Curr Top Membr. 2012; 70:105-68. DOI: 10.1016/B978-0-12-394316-3.00004-1. View

Slijepcevic D, Roscam Abbing R, Fuchs C, Haazen L, Beuers U, Trauner M . Na -taurocholate cotransporting polypeptide inhibition has hepatoprotective effects in cholestasis in mice. Hepatology. 2018; 68(3):1057-1069. PMC: 6175374. DOI: 10.1002/hep.29888. View

Asami J, Kimura K, Fujita-Fujiharu Y, Ishida H, Zhang Z, Nomura Y . Structure of the bile acid transporter and HBV receptor NTCP. Nature. 2022; 606(7916):1021-1026. DOI: 10.1038/s41586-022-04845-4. View

10.

Stieger B, Hagenbuch B, Landmann L, HOCHLI M, Schroeder A, Meier P . In situ localization of the hepatocytic Na+/Taurocholate cotransporting polypeptide in rat liver. Gastroenterology. 1994; 107(6):1781-7. DOI: 10.1016/0016-5085(94)90821-4. View

11.

Drew D, Boudker O . Shared Molecular Mechanisms of Membrane Transporters. Annu Rev Biochem. 2016; 85:543-72. DOI: 10.1146/annurev-biochem-060815-014520. View

12.

Dawson P, Lan T, Rao A . Bile acid transporters. J Lipid Res. 2009; 50(12):2340-57. PMC: 2781307. DOI: 10.1194/jlr.R900012-JLR200. View

13.

Hu N, Iwata S, Cameron A, Drew D . Crystal structure of a bacterial homologue of the bile acid sodium symporter ASBT. Nature. 2011; 478(7369):408-11. PMC: 3198845. DOI: 10.1038/nature10450. View