Structural Elucidation and Activities of -Derived Polysaccharides: A Review

Overview

Journal Front Nutr

Specialty Nutritional Sciences

Date 2022 Jun 17

PMID 35711557

Authors

Miao Miao

Wen-Qian Yu

Yuan Li

Yan-Long Sun

Shou-Dong Guo

Affiliations

Soon will be listed here.

Abstract

is a parasitic edible fungus and has been used as tonics for centuries. Polysaccharides are a major water-soluble component of . Recently, -derived polysaccharides have been given much attention due to their various actions including antioxidant, anti-inflammatory, anti-tumor, anti-hyperlipidemic, anti-diabetic, anti-atherosclerotic, and immunomodulatory effects. These bioactivities are determined by the various structural characteristics of polysaccharides including monosaccharide composition, molecular weight, and glycosidic linkage. The widespread use of advanced analytical analysis tools has greatly improved the elucidation of the structural characteristics of -derived polysaccharides. However, the methods for polysaccharide structural characterization and the latest findings related to -derived polysaccharides, especially the potential structure-activity relationship, have not been well-summarized in recent reviews of the literature. This review will discuss the methods used in the elucidation of the structure of polysaccharides and structural characteristics as well as the signaling pathways modulated by -derived polysaccharides. This article provides information useful for the development of -derived polysaccharides as well as for investigating other medicinal polysaccharides.

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References

Zhao W, Kirui A, Deligey F, Mentink-Vigier F, Zhou Y, Zhang B . Solid-state NMR of unlabeled plant cell walls: high-resolution structural analysis without isotopic enrichment. Biotechnol Biofuels. 2021; 14(1):14. PMC: 7792314. DOI: 10.1186/s13068-020-01858-x. View

Zhao W, Fernando L, Kirui A, Deligey F, Wang T . Solid-state NMR of plant and fungal cell walls: A critical review. Solid State Nucl Magn Reson. 2020; 107:101660. DOI: 10.1016/j.ssnmr.2020.101660. View

Tong L, Wang Y, Yuan L, Liu M, Du Y, Mu X . Enhancement of polysaccharides production using microparticle enhanced technology by Paraisaria dubia. Microb Cell Fact. 2022; 21(1):12. PMC: 8796560. DOI: 10.1186/s12934-021-01733-w. View

Jing Y, Cui X, Chen Z, Huang L, Song L, Liu T . Elucidation and biological activities of a new polysaccharide from cultured Cordyceps militaris. Carbohydr Polym. 2014; 102:288-96. DOI: 10.1016/j.carbpol.2013.11.061. View

Wu C, Liang Z, Tseng C, Hu S . Effects of Illumination Pattern during Cultivation of Fruiting Body and Bioactive Compound Production by the Caterpillar Medicinal Mushroom, Cordyceps militaris (Ascomycetes). Int J Med Mushrooms. 2016; 18(7):589-97. DOI: 10.1615/intjmedmushrooms.v18.i7.40. View

Reif B, Ashbrook S, Emsley L, Hong M . Solid-state NMR spectroscopy. Nat Rev Methods Primers. 2021; 1. PMC: 8341432. DOI: 10.1038/s43586-020-00002-1. View

Crea F . An update on triglyceride-rich lipoproteins and their remnants in atherosclerotic cardiovascular disease. Eur Heart J. 2021; 42(47):4777-4780. DOI: 10.1093/eurheartj/ehab844. View

Zhu Z, Liu F, Gao H, Sun H, Meng M, Zhang Y . Synthesis, characterization and antioxidant activity of selenium polysaccharide from Cordyceps militaris. Int J Biol Macromol. 2016; 93(Pt A):1090-1099. DOI: 10.1016/j.ijbiomac.2016.09.076. View

Yoo C, Sadat M, Kim W, Park T, Park D, Choi J . Comprehensive Transcriptomic Analysis of Cultivated on Germinated Soybeans. Mycobiology. 2022; 50(1):1-11. PMC: 8890544. DOI: 10.1080/12298093.2022.2035906. View

10.

Kim H, Kim J, Kang J, Kim H, Kim Y, Hong I . Cordlan polysaccharide isolated from mushroom Cordyceps militaris induces dendritic cell maturation through toll-like receptor 4 signalings. Food Chem Toxicol. 2010; 48(7):1926-33. DOI: 10.1016/j.fct.2010.04.036. View

11.

Wang C, Wu J, Chang C, Yu S, Liu Y . Enhanced exopolysaccharide production by Cordyceps militaris using repeated batch cultivation. J Biosci Bioeng. 2018; 127(4):499-505. DOI: 10.1016/j.jbiosc.2018.09.006. View

12.

Hu S, Wang J, Li F, Hou P, Yin J, Yang Z . Structural characterisation and cholesterol efflux improving capacity of the novel polysaccharides from Cordyceps militaris. Int J Biol Macromol. 2019; 131:264-272. DOI: 10.1016/j.ijbiomac.2019.03.078. View

13.

Phull A, Ahmed M, Park H . as a Bio Functional Food Source: Pharmacological Potential, Anti-Inflammatory Actions and Related Molecular Mechanisms. Microorganisms. 2022; 10(2). PMC: 8875674. DOI: 10.3390/microorganisms10020405. View

14.

Zhang Y, Zeng Y, Cui Y, Liu H, Dong C, Sun Y . Structural characterization, antioxidant and immunomodulatory activities of a neutral polysaccharide from Cordyceps militaris cultivated on hull-less barley. Carbohydr Polym. 2020; 235:115969. DOI: 10.1016/j.carbpol.2020.115969. View

15.

Zhao J, Xie J, Wang L, Li S . Advanced development in chemical analysis of Cordyceps. J Pharm Biomed Anal. 2013; 87:271-89. DOI: 10.1016/j.jpba.2013.04.025. View

16.

Gimeno A, Valverde P, Arda A, Jimenez-Barbero J . Glycan structures and their interactions with proteins. A NMR view. Curr Opin Struct Biol. 2019; 62:22-30. PMC: 7322516. DOI: 10.1016/j.sbi.2019.11.004. View

17.

Ren Y, Sun P, Ji Y, Wang X, Dai S, Zhu Z . Carboxymethylation and acetylation of the polysaccharide from and their α-glucosidase inhibitory activities. Nat Prod Res. 2019; 34(3):369-377. DOI: 10.1080/14786419.2018.1533830. View

18.

Liu X, Zhu Z, Liu Y, Sun H . Comparisons of the anti-tumor activity of polysaccharides from fermented mycelia and cultivated fruiting bodies of Cordyceps militaris in vitro. Int J Biol Macromol. 2019; 130:307-314. DOI: 10.1016/j.ijbiomac.2019.02.155. View

19.

Lee J, Kwon D, Lee K, Park J, Ha S, Hong E . Mechanism of macrophage activation induced by polysaccharide from Cordyceps militaris culture broth. Carbohydr Polym. 2015; 120:29-37. DOI: 10.1016/j.carbpol.2014.11.059. View

20.

Dao M, Everard A, Aron-Wisnewsky J, Sokolovska N, Prifti E, Verger E . Akkermansia muciniphila and improved metabolic health during a dietary intervention in obesity: relationship with gut microbiome richness and ecology. Gut. 2015; 65(3):426-36. DOI: 10.1136/gutjnl-2014-308778. View