Using the Dynamic Forward Scattering Signal for Optical Coherence Tomography Based Blood Flow Quantification

Overview

Journal Opt Lett

Specialty Ophthalmology

Date 2022 Jun 16

PMID 35709056

Authors

Ahhyun Stephanie Nam

Boy Braaf

Benjamin J Vakoc

Affiliations

Soon will be listed here.

Abstract

To our knowledge, all existing optical coherence tomography approaches for quantifying blood flow, whether Doppler-based or decorrelation-based, analyze light that is back-scattered by moving red blood cells (RBCs). This work investigates the potential advantages of basing these measurements on light that is forward-scattered by RBCs, i.e., by looking at the signals back-scattered from below the vessel. We show experimentally that flowmetry based on forward-scattering is insensitive to vessel orientation for vessels that are approximately orthogonal to the imaging beam. We further provide proof-of-principle demonstrations of dynamic forward-scattering (DFS) flowmetry in human retinal and choroidal vessels.

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