Update on Immune Mechanisms in Hypertension

Overview

Journal Am J Hypertens

Publisher Oxford University Press

Specialty Cardiology & Vascular Diseases

Date 2022 Jun 15

PMID 35704473

Authors

Shobana Navaneethabalakrishnan

Hannah L Smith

Cristina M Arenaz

Bethany L Goodlett

Justin G McDermott

Brett M Mitchell

Affiliations

Soon will be listed here.

Abstract

The contribution of immune cells in the initiation and maintenance of hypertension is undeniable. Several studies have established the association between hypertension, inflammation, and immune cells from the innate and adaptive immune systems. Here, we provide an update to our 2017 American Journal of Hypertension review on the overview of the cellular immune responses involved in hypertension. Further, we discuss the activation of immune cells and their contribution to the pathogenesis of hypertension in different in vivo models. We also highlight existing gaps in the field of hypertension that need attention. The main goal of this review is to provide a knowledge base for translational research to develop therapeutic strategies that can improve cardiovascular health in humans.

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